Research Papers: Imaging

Fluorescence diffuse optical tomography for free-space and multifluorophore studies

[+] Author Affiliations
Anne Koenig, Lionel Hervé, Georges Gonon

CEA-LETI, Minatec, 17 Rue des Martyrs, Grenoble Cedex 9, 38054, France

Véronique Josserand

Institut Albert Bonniot, INSERM U823, La Tronche Cedex 9, 38706, France

Michel Berger, Jean-Marc Dinten, Jérôme Boutet, Philippe Peltié

CEA-LETI, Minatec, 17 Rue des Martyrs, Grenoble Cedex 9, 38054, France

Jean-Luc Coll

Institut Albert Bonniot, INSERM U823, La Tronche Cedex 9, 38706, France

Philippe Rizo

CEA-LETI, Minatec, 17 Rue des Martyrs, Grenoble Cedex 9, 38054, France

J. Biomed. Opt. 15(1), 016016 (March 01, 2010). doi:10.1117/1.3309738
History: Received December 23, 2008; Revised December 04, 2009; Accepted December 04, 2009; Published March 01, 2010; Online March 01, 2010
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We present two major advances in preclinical fluorescence-enhanced diffuse optical tomography (fDOT) system and assess its performance. It is now possible to perform experiments without adaptation liquid or a glass plate over the animal, and our system is equipped with a filter wheel in order to discriminate two injected fluorophores. Evaluation carried out on characterization phantoms and in vivo on mice demonstrates enriched use of the system for biological studies on small animals.

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© 2010 Society of Photo-Optical Instrumentation Engineers

Citation

Anne Koenig ; Lionel Hervé ; Georges Gonon ; Véronique Josserand ; Michel Berger, et al.
"Fluorescence diffuse optical tomography for free-space and multifluorophore studies", J. Biomed. Opt. 15(1), 016016 (March 01, 2010). ; http://dx.doi.org/10.1117/1.3309738


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