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Special Section on Photons Plus Ultrasound: Imaging and Sensing

Photoacoustic microscopy with 2-μm transverse resolution

[+] Author Affiliations
Geng Ku, Konstantin Maslov, Li Li, Lihong V. Wang

Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, Campus Box 1097, 1 Brookings Drive, St. Louis, Missouri 63130

J. Biomed. Opt. 15(2), 021302 (July 31, 2009December 16, 2009December 17, 2009March 25, 2010March 25, 2010). doi:10.1117/1.3339912
History: Received July 31, 2009; Revised December 16, 2009; Accepted December 17, 2009; Published March 25, 2010; Online March 25, 2010
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We present a new-generation optical-resolution confocal photoacoustic microscope, consisting of a 0.25–numerical aperture optical microscope objective and a 75-MHz center-frequency spherically focused ultrasonic transducer. Experiments verified that this microscope has a transverse resolution of 2μm, which is the highest to our knowledge among all photoacoustic imaging systems. In situ imaging of mouse ears shows the feasibility of resolving individual red blood cells in microvessels using the current system.

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© 2010 Society of Photo-Optical Instrumentation Engineers

Citation

Geng Ku ; Konstantin Maslov ; Li Li and Lihong V. Wang
"Photoacoustic microscopy with 2-μm transverse resolution", J. Biomed. Opt. 15(2), 021302 (July 31, 2009December 16, 2009December 17, 2009March 25, 2010March 25, 2010). ; http://dx.doi.org/10.1117/1.3339912


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