Special Section on Photons Plus Ultrasound: Imaging and Sensing

Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo

[+] Author Affiliations
Liang Song, Konstantin Maslov

Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, One Brookings Drive, St. Louis, Missouri 63130

K. Kirk Shung

University of Southern California, Department of Biomedical Engineering, 1042 Downey Way, Los Angeles, California 90089

Lihong V. Wang

Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, One Brookings Drive, St. Louis, Missouri 63130

J. Biomed. Opt. 15(2), 021303 (March 11, 2010). doi:10.1117/1.3333545
History: Received July 08, 2009; Revised September 15, 2009; Accepted September 22, 2009; Published March 11, 2010; Online March 11, 2010
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With a refined ultrasound-array-based real-time photoacoustic microscopy (UA-PAM) system, we demonstrate the feasibility of noninvasive in vivo imaging of human pulsatile dynamics. The system, capable of real-time B-scan imaging at 50Hz and high-speed 3-D imaging, is validated by imaging the subcutaneous microvasculature in rats and humans. After the validation, a human artery around the palm-wrist area is imaged, and its pulsatile dynamics, including the arterial pulsatile motion and changes in hemoglobin concentration, is monitored with 20-ms B-scan imaging temporal resolution. To our knowledge, this is the first demonstration of real-time photoacoustic imaging of human physiological dynamics. Our results show that UA-PAM can potentially enable many new possibilities for studying functional and physiological dynamics in both preclinical and clinical imaging settings.

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© 2010 Society of Photo-Optical Instrumentation Engineers

Citation

Liang Song ; Konstantin Maslov ; K. Kirk Shung and Lihong V. Wang
"Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo", J. Biomed. Opt. 15(2), 021303 (March 11, 2010). ; http://dx.doi.org/10.1117/1.3333545


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