Special Section on Photons Plus Ultrasound: Imaging and Sensing

Photoacoustic microtomography using optical interferometric detection

[+] Author Affiliations
Robert Nuster

Karl-Franzens-University of Graz, Department of Physics, Universitätsplatz 5, Graz, 8010 Austria

Markus Holotta, Christian Kremser

University Hospital of Innsbruck, Department of Radiodiagnostics, Innsbruck, 6020 Austria

Harald Grossauer

University of Innsbruck, Department of Mathematics, Innsbruck, 6020 Austria

Peter Burgholzer

RECENDT Research Center for Non Destructive Testing GmbH, Hafenstrasse 47-51, Linz, 4020 Austria

Günther Paltauf

Karl-Franzens-University of Graz, Department of Physics, Universitätsplatz 5, Graz, 8010 Austria

J. Biomed. Opt. 15(2), 021307 (March 11, 2010). doi:10.1117/1.3333547
History: Received August 14, 2009; Accepted October 23, 2009; Published March 11, 2010; Online March 11, 2010
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A device for three-dimensional (3-D) photoacoustic tomography with resolution in the range of tens of micrometers is presented that uses a light beam for interferometric detection of acoustic waves. Reconstruction of the 3-D initial pressure distribution from the signals representing line integrals of the acoustic field is a two-step process. It uses an inversion of 2-D wave propagation to obtain line projections of the initial pressure distribution and the inverse Radon transform. The light beam, propagating freely in a water bath, is scanned either in an arc- or box-shaped curve around the object. Simulations are performed to compare the two scanning procedures. The projection images are obtained either using the filtered back projection algorithm for the π-arc scanning mode or the frequency domain algorithm for the box scanning mode. While the former algorithm provides slightly better image quality, the latter is about 20 times faster. The ability of the photoacoustic tomography device to create 3-D images with constant resolution throughout the reconstruction volume is demonstrated experimentally using a human hair phantom. These measurements revealed a 3-D resolution below 100μm. In a second experiment, 3-D imaging of an isolated mouse heart is demonstrated to show the applicability for preclinical and biological research.

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© 2010 Society of Photo-Optical Instrumentation Engineers

Citation

Robert Nuster ; Markus Holotta ; Christian Kremser ; Harald Grossauer ; Peter Burgholzer, et al.
"Photoacoustic microtomography using optical interferometric detection", J. Biomed. Opt. 15(2), 021307 (March 11, 2010). ; http://dx.doi.org/10.1117/1.3333547


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