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Special Section on Photons Plus Ultrasound: Imaging and Sensing

Optoacoustic imaging of the prostate: development toward image-guided biopsy

[+] Author Affiliations
Mohammad A. Yaseen, Sergey A. Ermilov, Hans-Peter Brecht, Richard Su, André Conjusteau

Fairway Medical Technologies Inc., 710 North Post Oak Road, Suite 204, Houston, Texas 77024

Matthew Fronheiser

Seno Medical Instruments, Inc., 3838 Medical Drive, Suite 101, San Antonio, Texas 78229

Brent A. Bell, Massoud Motamedi

Center for Biomedical Engineering, University of Texas, Medical Branch, Galveston, Texas 77555

Alexander A. Oraevsky

Fairway Medical Technologies Inc., 710 North Post Oak Road, Suite 204, Houston, Texas 77024

J. Biomed. Opt. 15(2), 021310 (August 14, 2009October 14, 2009October 26, 2009March 12, 2010March 12, 2010). doi:10.1117/1.3333548
History: Received August 14, 2009; Revised October 14, 2009; Accepted October 26, 2009; Published March 12, 2010; Online March 12, 2010
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Optoacoustic (OA) tomography has demonstrated utility in identifying blood-rich malignancies in breast tissue. We describe the development and characterization of a laser OA imaging system for the prostate (LOIS-P). The system consists of a fiber-coupled Q-switched laser operating at 757nm, a commercial 128-channel ultrasonic probe, a digital signal processor, and software that uses the filtered radial back-projection algorithm for image reconstruction. The system is used to reconstruct OA images of a blood-rich lesion induced in vivo in a canine prostate. OA images obtained in vivo are compared to images acquired using ultrasound, the current gold standard for guiding biopsy of the prostate. Although key structural features such as the urethra could be identified with both imaging techniques, a bloody lesion representing a highly vascularized tumor could only be clearly identified in OA images. The advantages and limitations of both forward and backward illumination modes are also evaluated by collecting OA images of phantoms simulating blood vessels within tissue. System resolution is estimated to be 0.2mm in the radial direction of the acoustic array. The minimum detectable pressure signal is 1.83Pa. Our results encourage further development toward a dual-modality OA/ultrasonic system for prostate imaging and image-guided biopsy.

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Ta2, Light Age Inc., Somerset, New Jersey

Citation

Mohammad A. Yaseen ; Matthew Fronheiser ; Brent A. Bell ; Alexander A. Oraevsky ; Massoud Motamedi, et al.
"Optoacoustic imaging of the prostate: development toward image-guided biopsy", J. Biomed. Opt. 15(2), 021310 (August 14, 2009October 14, 2009October 26, 2009March 12, 2010March 12, 2010). ; http://dx.doi.org/10.1117/1.3333548


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