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Special Section on Photons Plus Ultrasound: Imaging and Sensing

Silver nanosystems for photoacoustic imaging and image-guided therapy

[+] Author Affiliations
Kimberly Homan, Jignesh Shah, Sobeyda Gomez, Heidi Gensler, Andrei Karpiouk

The University of Texas at Austin, Biomedical Engineering Department, 1 University Station C0800, Austin, Texas 78712

Lisa Brannon-Peppas

PeppChem Consulting, 3267 Bee Caves Road, Suite 107-239, Austin, Texas 78746-6700

Stanislav Emelianov

The University of Texas at Austin, Biomedical Engineering Department, 1 University Station C0800, Austin, Texas 78712

J. Biomed. Opt. 15(2), 021316 (August 18, 2009January 05, 2010January 06, 2010March 29, 2010March 29, 2010). doi:10.1117/1.3365937
History: Received August 18, 2009; Revised January 05, 2010; Accepted January 06, 2010; Published March 29, 2010; Online March 29, 2010
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Due to their optical absorption properties, metallic nanoparticles are excellent photoacoustic imaging contrast agents. A silver nanosystem is presented here as a potential contrast agent for photoacoustic imaging and image-guided therapy. Currently, the nanosystem consists of a porous silver layer deposited on the surface of spherical silica cores ranging in diameter from 180to520nm. The porous nature of the silver layer will allow for release of drugs or other therapeutic agents encapsulated in the core in future applications. In their current PEGylated form, the silver nanosystem is shown to be nontoxic in vitro at concentrations of silver up to 2mgml. Furthermore, the near-infrared absorbance properties of the nanosystem are demonstrated by measuring strong, concentration-dependent photoacoustic signal from the silver nanosystem embedded in an ex vivo tissue sample. Our study suggests that silver nanosystems can be used as multifunctional agents capable of augmenting image-guided therapy techniques.

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Citation

Kimberly Homan ; Lisa Brannon-Peppas ; Stanislav Emelianov ; Jignesh Shah ; Sobeyda Gomez, et al.
"Silver nanosystems for photoacoustic imaging and image-guided therapy", J. Biomed. Opt. 15(2), 021316 (August 18, 2009January 05, 2010January 06, 2010March 29, 2010March 29, 2010). ; http://dx.doi.org/10.1117/1.3365937


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