Research Papers: Imaging

Light shadowing effect of large breast lesions imaged by optical tomography in reflection geometry

[+] Author Affiliations
Chen Xu, Quing Zhu

University of Connecticut, Department of Electrical and Computer Engineering, 371 Fairfield Road, Storrs, Connecticut 06269

J. Biomed. Opt. 15(3), 036003 (May 27, 2010). doi:10.1117/1.3431086
History: Received November 18, 2009; Revised March 14, 2010; Accepted March 16, 2010; Published May 27, 2010; Online May 27, 2010
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When a large, highly absorbing breast lesion is imaged by optical tomography in reflection geometry, most of the photons are absorbed by the top portion of the lesion. As a result, the lower portion of the lesion is not quantified correctly. This posterior light shadowing effect is similar to the sound shadowing effect frequently seen in pulse-echo ultrasound images. The presence of significant posterior shadowing of a lesion in ultrasound images suggests malignance. The light shadowing effect due to optical contrast is characterized using a simple measure and validated by the Monte Carlo photon-tracking method and phantom experiments. Clinical examples of large malignant and benign lesions are presented to demonstrate the shadowing effect and the utility of the measure. Understanding and quantifying the shadowing effect due to optical contrast is important for characterizing larger malignant cancers from benign lesions.

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© 2010 Society of Photo-Optical Instrumentation Engineers

Citation

Chen Xu and Quing Zhu
"Light shadowing effect of large breast lesions imaged by optical tomography in reflection geometry", J. Biomed. Opt. 15(3), 036003 (May 27, 2010). ; http://dx.doi.org/10.1117/1.3431086


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