Research Papers: Imaging

Identification of abnormal motor cortex activation patterns in children with cerebral palsy by functional near-infrared spectroscopy

[+] Author Affiliations
Bilal Khan, Fenghua Tian, Khosrow Behbehani, Mario I. Romero

University of Texas at Arlington and University of Texas Southwestern Medical Center at Dallas, Joint Graduate Program in Biomedical Engineering, Arlington, Texas 76019

Mauricio R. Delgado, Nancy J. Clegg, Linsley Smith, Dahlia Reid

Texas Scottish Rite Hospital for Children, Department of Neurology, 2222 Welborn Street, Dallas, Texas 75219

Hanli Liu, George Alexandrakis

University of Texas at Arlington and University of Texas Southwestern Medical Center at Dallas, Joint Graduate Program in Biomedical Engineering, Arlington, Texas 76019

J. Biomed. Opt. 15(3), 036008 (May 26, 2010). doi:10.1117/1.3432746
History: Received December 14, 2009; Revised March 09, 2010; Accepted March 23, 2010; Published May 26, 2010; Online May 26, 2010
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We demonstrate the utility of functional near-infrared spectroscopy (fNIRS) as a tool for physicians to study cortical plasticity in children with cerebral palsy (CP). Motor cortex activation patterns were studied in five healthy children and five children with CP (8.4±2.3years old in both groups) performing a finger-tapping protocol. Spatial (distance from center and area difference) and temporal (duration and time-to-peak) image metrics are proposed as potential biomarkers for differentiating abnormal cortical activation in children with CP from healthy pediatric controls. In addition, a similarity image-analysis concept is presented that unveils areas that have similar activation patterns as that of the maximum activation area, but are not discernible by visual inspection of standard activation images. Metrics derived from the images presenting areas of similarity are shown to be sensitive identifiers of abnormal activation patterns in children with CP. Importantly, the proposed similarity concept and related metrics may be applicable to other studies for the identification of cortical activation patterns by fNIRS.

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© 2010 Society of Photo-Optical Instrumentation Engineers

Citation

Bilal Khan ; Fenghua Tian ; Khosrow Behbehani ; Mario I. Romero ; Mauricio R. Delgado, et al.
"Identification of abnormal motor cortex activation patterns in children with cerebral palsy by functional near-infrared spectroscopy", J. Biomed. Opt. 15(3), 036008 (May 26, 2010). ; http://dx.doi.org/10.1117/1.3432746


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