Research Papers: Therapeutic

Modulated and continuous-wave operations of low-power thulium (Tm:YAP) laser in tissue welding

[+] Author Affiliations
Temel Bilici, Haşim Özgür Tabakoğlu, Nermin Topaloğlu

Bogaziçi University, Biomedical Engineering Institute, Biophotonics Laboratory, Istanbul, 34342 Turkey

Hamit Kalaycıoğlu

Koç University, Department of Physics, Laser Research Laboratory, Istanbul, 34450 Turkey

Adnan Kurt

Teknofil Ltd., Sti. Zekeriyaköy, Istanbul, 34450 Turkey

Alphan Sennaroglu

Koç University, Department of Physics, Laser Research Laboratory, Istanbul, 34450 Turkey

Murat Gülsoy

Bogaziçi University, Biomedical Engineering Institute, Biophotonics Laboratory, Istanbul, 34342 Turkey

J. Biomed. Opt. 15(3), 038001 (May 26, 2010). doi:10.1117/1.3431108
History: Received December 03, 2009; Revised March 14, 2010; Accepted March 30, 2010; Published May 26, 2010; Online May 26, 2010
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Our aim is to explore the welding capabilities of a thulium (Tm:YAP) laser in modulated and continuous-wave (CW) modes of operation. The Tm:YAP laser system developed for this study includes a Tm:YAP laser resonator, diode laser driver, water chiller, modulation controller unit, and acquisition/control software. Full-thickness incisions on Wistar rat skin were welded by the Tm:YAP laser system at 100mW and 5s in both modulated and CW modes of operation (34.66Wcm2). The skin samples were examined during a 21-day healing period by histology and tensile tests. The results were compared with the samples closed by conventional suture technique. For the laser groups, immediate closure at the surface layers of the incisions was observed. Full closures were observed for both modulated and CW modes of operation at day 4. The tensile forces for both modulated and CW modes of operation were found to be significantly higher than the values found by conventional suture technique. The 1980-nm Tm:YAP laser system operating in both modulated and CW modes maximizes the therapeutic effect while minimizing undesired side effects of laser tissue welding. Hence, it is a potentially important alternative tool to the conventional suturing technique.

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© 2010 Society of Photo-Optical Instrumentation Engineers

Citation

Temel Bilici ; Haşim Özgür Tabakoğlu ; Nermin Topaloğlu ; Hamit Kalaycıoğlu ; Adnan Kurt, et al.
"Modulated and continuous-wave operations of low-power thulium (Tm:YAP) laser in tissue welding", J. Biomed. Opt. 15(3), 038001 (May 26, 2010). ; http://dx.doi.org/10.1117/1.3431108


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