Research Papers: General

Computational study of scattering from healthy and diseased red blood cells

[+] Author Affiliations
Özgür Ergül

University of Strathclyde, Department of Mathematics and Statistics, Glasgow, Scotland, G1 1XH, United Kingdom

Ayça Arslan-Ergül

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland, G4 0NR, United Kingdom

Levent Gürel

Bilkent University, Department of Electrical and Electronics Engineering and Computational Electromagnetics Research Center (BiLCEM), TR-06800 Bilkent, Ankara, Turkey

J. Biomed. Opt. 15(4), 045004 (August 05, 2010). doi:10.1117/1.3467493
History: Received September 28, 2009; Revised April 24, 2010; Accepted May 26, 2010; Published August 05, 2010; Online August 05, 2010
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We present a comparative study of scattering from healthy red blood cells (RBCs) and diseased RBCs with deformed shapes. Scattering problems involving three-dimensional RBCs are formulated accurately with the electric and magnetic current combined-field integral equation and solved efficiently by the multilevel fast multipole algorithm. We compare scattering cross section values obtained for different RBC shapes and different orientations. In this way, we determine strict guidelines to distinguish deformed RBCs from healthy RBCs and to diagnose various diseases using scattering cross section values. The results may be useful for designing new and improved flow cytometry procedures.

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© 2010 Society of Photo-Optical Instrumentation Engineers

Citation

Özgür Ergül ; Ayça Arslan-Ergül and Levent Gürel
"Computational study of scattering from healthy and diseased red blood cells", J. Biomed. Opt. 15(4), 045004 (August 05, 2010). ; http://dx.doi.org/10.1117/1.3467493


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