Research Papers: Imaging

In-vivo dynamic characterization of microneedle skin penetration using optical coherence tomography

[+] Author Affiliations
Joey Enfield, Marie-Louise O’Connell, Kate Lawlor, Enock Jonathan

University of Limerick, Department of Physics and Tissue Optics and Microcirculation Imaging Facility, National Biophotonics and Imaging Platform, Limerick, Ireland

Conor O’Mahony

Tyndall National Institute, Microsystems Centre, Cork, Ireland

Martin Leahy

University of Limerick, Department of Physics and Tissue Optics and Microcirculation Imaging Facility, National Biophotonics and Imaging Platform, Limerick, Ireland and Royal College of Surgeons, Dublin, Ireland

J. Biomed. Opt. 15(4), 046001 (August 06, 2010). doi:10.1117/1.3463002
History: Received July 17, 2009; Revised March 28, 2010; Accepted May 12, 2010; Published August 06, 2010; Online August 06, 2010
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The use of microneedles as a method of circumventing the barrier properties of the stratum corneum is receiving much attention. Although skin disruption technologies and subsequent transdermal diffusion rates are being extensively studied, no accurate data on depth and closure kinetics of microneedle-induced skin pores are available, primarily due to the cumbersome techniques currently required for skin analysis. We report on the first use of optical coherence tomography technology to image microneedle penetration in real time and in vivo. We show that optical coherence tomography (OCT) can be used to painlessly measure stratum corneum and epidermis thickness, as well as microneedle penetration depth after microneedle insertion. Since OCT is a real-time, in-vivo, nondestructive technique, we also analyze skin healing characteristics and present quantitative data on micropore closure rate. Two locations (the volar forearm and dorsal aspect of the fingertip) have been assessed as suitable candidates for microneedle administration. The results illustrate the applicability of OCT analysis as a tool for microneedle-related skin characterization.

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© 2010 Society of Photo-Optical Instrumentation Engineers

Citation

Joey Enfield ; Marie-Louise O’Connell ; Kate Lawlor ; Enock Jonathan ; Conor O’Mahony, et al.
"In-vivo dynamic characterization of microneedle skin penetration using optical coherence tomography", J. Biomed. Opt. 15(4), 046001 (August 06, 2010). ; http://dx.doi.org/10.1117/1.3463002


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