Research Papers: Imaging

Comprehensive investigation of three-dimensional diffuse optical tomography with depth compensation algorithm

[+] Author Affiliations
Haijing Niu, Zi-Jing Lin, Fenghua Tian, Sameer Dhamne, Hanli Liu

University of Texas at Arlington, Department of Bioengineering, Joint Graduate Program between University of Texas at Arlington and University of Texas Southwestern Medical Center, Arlington, Texas 76019

J. Biomed. Opt. 15(4), 046005 (July 21, 2010). doi:10.1117/1.3462986
History: Received February 24, 2010; Revised May 12, 2010; Accepted May 18, 2010; Published July 21, 2010; Online July 21, 2010
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A depth compensation algorithm (DCA) can effectively improve the depth localization of diffuse optical tomography (DOT) by compensating the exponentially decreased sensitivity in the deep tissue. In this study, DCA is investigated based on computer simulations, tissue phantom experiments, and human brain imaging. The simulations show that DCA can largely improve the spatial resolution of DOT in addition to the depth localization, and DCA is also effective for multispectral DOT with a wide range of optical properties in the background tissue. The laboratory phantom experiment demonstrates that DCA can effectively differentiate two embedded objects at different depths in the medium. DCA is further validated by human brain imaging using a finger-tapping task. To our knowledge, this is the first demonstration to show that DCA is capable of accurately localizing cortical activations in the human brain in three dimensions.

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© 2010 Society of Photo-Optical Instrumentation Engineers

Citation

Haijing Niu ; Zi-Jing Lin ; Fenghua Tian ; Sameer Dhamne and Hanli Liu
"Comprehensive investigation of three-dimensional diffuse optical tomography with depth compensation algorithm", J. Biomed. Opt. 15(4), 046005 (July 21, 2010). ; http://dx.doi.org/10.1117/1.3462986


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