Research Papers: Imaging

Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes

[+] Author Affiliations
Chulhong Kim

Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130-4899

Todd N. Erpelding

Philips Research North America, 345 Scarborough Road, Briarcliff Manor, New York 10510

Konstantin Maslov

Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130-4899

Ladislav Jankovic

Philips Research North America, 345 Scarborough Road, Briarcliff Manor, New York 10510

Walter J. Akers

Washington University School of Medicine, Department of Radiology and Department of Biophysics, Optical Radiology Laboratory, 4525 Scott Avenue, Saint Louis, Missouri 63108

Liang Song

Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130-4899

Samuel Achilefu

Washington University School of Medicine, Department of Radiology and Department of Biophysics, Optical Radiology Laboratory, 4525 Scott Avenue, Saint Louis, Missouri 63108

Julie A. Margenthaler

Washington University School of Medicine, Department of Surgery, Campus Box 8109, 660 South Euclid Avenue, St. Louis, Missouri 63110

Michael D. Pashley

Philips Research North America, 345 Scarborough Road, Briarcliff Manor, New York 10510

Lihong V. Wang

Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130-4899

J. Biomed. Opt. 15(4), 046010 (August 16, 2010). doi:10.1117/1.3469829
History: Received March 26, 2010; Revised May 25, 2010; Accepted May 28, 2010; Published August 16, 2010; Online August 16, 2010
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By modifying a clinical ultrasound array system, we develop a novel handheld photoacoustic probe for image-guided needle biopsy. The integration of optical fiber bundles for pulsed laser light delivery enables photoacoustic image-guided insertion of a needle into rat axillary lymph nodes with accumulated indocyanine green (ICG). Strong photoacoustic contrast of the needle is achieved. After subcutaneous injection of the dye in the left forepaw, sentinel lymph nodes are easily detected, in vivo and in real time, beneath 2-cm-thick chicken breast overlaying the axillary region. ICG uptake in axillary lymph nodes is confirmed with fluorescence imaging both in vivo and ex vivo. These results demonstrate the clinical potential of this handheld photoacoustic system for facile identification and needle biopsy of sentinel lymph nodes for cancer staging and metastasis detection in humans.

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© 2010 Society of Photo-Optical Instrumentation Engineers

Citation

Chulhong Kim ; Todd N. Erpelding ; Konstantin Maslov ; Ladislav Jankovic ; Walter J. Akers, et al.
"Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes", J. Biomed. Opt. 15(4), 046010 (August 16, 2010). ; http://dx.doi.org/10.1117/1.3469829


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