Research Papers: Imaging

Intravascular optical coherence tomography on a beating heart model

[+] Author Affiliations
Guy Lamouche, Marc Dufour

Conseil National de Recherches Canada, Institut des Matériaux Industriels, 75 de Mortagne, Boucherville, Quebec J4B 6Y4, Canada

Mark Hewko

National Research Council Canada, Institute for Biodiagnostics, 435 Ellice Avenue, Winnipeg, Manitoba R3B 1Y6, Canada

Sébastien Vergnole, Bruno Gauthier, Charles-Étienne Bisaillon, Jean-Pierre Monchalin

Conseil National de Recherches Canada, Institut des Matériaux Industriels, 75 de Mortagne, Boucherville, Quebec J4B 6Y4, Canada

Michael G. Sowa

National Research Council Canada, Institute for Biodiagnostics, 435 Ellice Avenue, Winnipeg, Manitoba R3B 1Y6, Canada

J. Biomed. Opt. 15(4), 046023 (August 09, 2010). doi:10.1117/1.3475960
History: Received January 15, 2010; Revised May 25, 2010; Accepted June 23, 2010; Published August 09, 2010; Online August 09, 2010
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The advantages and limitations of using a beating heart model in the development of intravascular optical coherence tomography are discussed. The model fills the gap between bench experiments, performed on phantoms and excised arteries, and whole animal in-vivo preparations. The beating heart model is stable for many hours, allowing for extended measurement times and multiple imaging sessions under in-vivo conditions without the complications of maintaining whole-animal preparation. The perfusate supplying the heart with nutrients can be switched between light scattering blood to a nonscattering perfusate to allow the optical system to be optimized without the need of an efficient blood displacement strategy. Direct access to the coronary vessels means that there is no need for x-ray fluoroscopic guidance of the catheter to the heart, as is the case in whole animal preparation. The model proves to be a valuable asset in the development of our intravascular optical coherence tomography technology.

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© 2010 Society of Photo-Optical Instrumentation Engineers

Citation

Guy Lamouche ; Marc Dufour ; Mark Hewko ; Sébastien Vergnole ; Bruno Gauthier, et al.
"Intravascular optical coherence tomography on a beating heart model", J. Biomed. Opt. 15(4), 046023 (August 09, 2010). ; http://dx.doi.org/10.1117/1.3475960


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