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Research Papers: Imaging

Phase-sensitive optical coherence tomography imaging of the tissue motion within the organ of Corti at a subnanometer scale: a preliminary study

[+] Author Affiliations
Ruikang K. Wang

Oregon Health & Science University, Department of Biomedical Engineering and Department of Anesthesiology and Peri-Operative Medicine, CH13B, 3303 Southwest Bond Avenue, Portland, Oregon 97239

Alfred L. Nuttall

Oregon Health & Science University, Department of Biomedical Engineering, CH13B, 3303 Southwest Bond Avenue, Portland, Oregon 97239 and Oregon Health & Science University, Oregon Hearing Research Center, NRC04, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97239

J. Biomed. Opt. 15(5), 056005 (September 10, 2010). doi:10.1117/1.3486543
History: Received March 19, 2010; Revised July 05, 2010; Accepted July 23, 2010; Published September 10, 2010; Online September 10, 2010
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Hearing loss can mean severe impairment to the quality of life. However, the biomechanical mechanisms of how the hearing organ, i.e., the organ of Corti (OC), responds to sound are still elusive, largely because there is currently no means available to image the 3-D motion characteristics of the OC. We present a novel use of the phase-sensitive spectral domain optical coherence tomography (PSOCT) to characterize the motion of cellular compartments within the OC at a subnanometer scale. The PSOCT system operates at 1310nm with a spatial resolution of 16μm and an imaging speed of 47,000 A-lines/s. The phase changes of the spectral interferograms induced by the localized tissue motion are used to quantify the vibration magnitude. Fourier transform analysis of the phase changes improves the system sensitivity to sense minute vibrations smaller than 1nm. We demonstrate that the PSOCT system is feasible to image the meaningful vibration of cellular compartments within the OC with an unprecedented sensitivity down to 0.5Å.

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© 2010 Society of Photo-Optical Instrumentation Engineers

Citation

Ruikang K. Wang and Alfred L. Nuttall
"Phase-sensitive optical coherence tomography imaging of the tissue motion within the organ of Corti at a subnanometer scale: a preliminary study", J. Biomed. Opt. 15(5), 056005 (September 10, 2010). ; http://dx.doi.org/10.1117/1.3486543


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