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Research Papers: Imaging

Digital holographic microscopy by use of surface plasmon resonance for imaging of cell membranes

[+] Author Affiliations
Cuiying Hu

Jinan University, Department of Optoelectronic Engineering, Guangzhou 510632, China

Jingang Zhong

Jinan University, Department of Optoelectronic Engineering and Jinan University, Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong, Higher Education Institutes, Guangzhou 510632, China

Jiawen Weng

Jinan University, Department of Optoelectronic Engineering, Guangzhou 510632, China

J. Biomed. Opt. 15(5), 056015 (October 06, 2010). doi:10.1117/1.3497564
History: Received January 15, 2010; Revised August 20, 2010; Accepted August 26, 2010; Published October 06, 2010; Online October 06, 2010
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A technique called surface plasmon resonance digital holographic microscopy (SPRDHM) for optical imaging of cell membranes is proposed. The intensity and phase distributions of the reflected light that is modulated by the cell membrane in surface plasmon resonance can be simultaneously obtained. The imaging principle and capability are theoretically analyzed and demonstrated by experiments. In addition, the technique is compared with total internal reflection digital holographic microscopy (TIRDHM) in theory and experiment, respectively. The results show that the SPRDHM technique is better in spatial resolution and phase sensitivity than the TIRDHM technique for imaging of cell membranes.

© 2010 Society of Photo-Optical Instrumentation Engineers

Citation

Cuiying Hu ; Jingang Zhong and Jiawen Weng
"Digital holographic microscopy by use of surface plasmon resonance for imaging of cell membranes", J. Biomed. Opt. 15(5), 056015 (October 06, 2010). ; http://dx.doi.org/10.1117/1.3497564


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