Research Papers: Therapeutic

System for interstitial photodynamic therapy with online dosimetry: first clinical experiences of prostate cancer

[+] Author Affiliations
Johannes Swartling

SpectraCure AB, Magistratsvägen 10, SE-226 43 Lund, Sweden

Johan Axelsson

Lund University, Department of Physics, P.O. Box 118, SE-221 00 Lund, Sweden

Göran Ahlgren

Malmö University Hospital, Department of Urology, SE-205 02 Malmö, Sweden

Karl Mikael Kälkner, Sten Nilsson

Karolinska University Hospital, Department of Oncology, Radiumhemmet, SE-171 76 Stockholm, Sweden

Sune Svanberg

Lund University, Department of Physics, P.O. Box 118, SE-221 00 Lund, Sweden

Katarina Svanberg

Lund University Hospital, Department of Oncology, SE-221 85 Lund, Sweden

Stefan Andersson-Engels

Lund University, Department of Physics, P.O. Box 118, SE-221 00 Lund, Sweden

J. Biomed. Opt. 15(5), 058003 (October 27, 2010). doi:10.1117/1.3495720
History: Received April 09, 2010; Revised August 19, 2010; Accepted August 20, 2010; Published October 27, 2010; Online October 27, 2010
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The first results from a clinical study for Temoporfin-mediated photodynamic therapy (PDT) of low-grade (T1c) primary prostate cancer using online dosimetry are presented. Dosimetric feedback in real time was applied, for the first time to our knowledge, in interstitial photodynamic therapy. The dosimetry software IDOSE provided dose plans, including optical fiber positions and light doses based on 3-D tissue models generated from ultrasound images. Tissue optical property measurements were obtained using the same fibers used for light delivery. Measurements were taken before, during, and after the treatment session. On the basis of these real-time measured optical properties, the light-dose plan was recalculated. The aim of the treatment was to ablate the entire prostate while minimizing exposure to surrounding organs. The results indicate that online dosimetry based on real-time tissue optical property measurements enabled the light dose to be adapted and optimized. However, histopathological analysis of tissue biopsies taken six months post-PDT treatment showed there were still residual viable cancer cells present in the prostate tissue sections. The authors propose that the incomplete treatment of the prostate tissue could be due to a too low light threshold dose, which was set to 5Jcm2.

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© 2010 Society of Photo-Optical Instrumentation Engineers

Citation

Johannes Swartling ; Johan Axelsson ; Göran Ahlgren ; Karl Mikael Kälkner ; Sten Nilsson, et al.
"System for interstitial photodynamic therapy with online dosimetry: first clinical experiences of prostate cancer", J. Biomed. Opt. 15(5), 058003 (October 27, 2010). ; http://dx.doi.org/10.1117/1.3495720


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