Special Section on Optical Diagnostic and Biophotonic Methods from Bench to Bedside

Angular domain transillumination imaging optimization with an ultrafast gated camera

[+] Author Affiliations
Fartash Vasefi, Mohamadreza Najiminaini

Simon Fraser University The School of Engineering Science Burnaby, British Columbia, Canada and Lawson Health Research Institute St. Joseph's Health Care Imaging Program London, Ontario, Canada

Eldon Ng

Lawson Health Research Institute St. Joseph's Health Care Imaging Program London, Ontario, Canada and University of Western Ontario Schulich School of Medicine and Dentistry Medical Biophysics London, Ontario, Canada

Bozena Kaminska, Glenn H. Chapman

Simon Fraser University The School of Engineering Science Burnaby, British Columbia, Canada

Jeffery J. L. Carson

Lawson Health Research Institute St. Joseph's Health Care Imaging Program London, Ontario, Canada and University of Western Ontario Schulich School of Medicine and Dentistry Medical Biophysics London, Ontario, Canada

J. Biomed. Opt. 15(6), 061710 (November 17, 2010). doi:10.1117/1.3505020
History: Received February 10, 2010; Revised August 26, 2010; Accepted September 10, 2010; Published November 17, 2010; Online November 17, 2010
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By employing high-aspect-ratio parallel microchannels as an angular filter, quasiballistic photons sensitive to internal structures in a turbid medium can be captured. Scattered photons exiting the turbid medium typically exhibit trajectories with random angles compared to the initial trajectory and are mostly rejected by the filter. However, angular filter arrays cannot differentiate between quasiballistic photons (early arriving) and photons that happen to attain a scattered trajectory that is within the acceptance angle (late arriving). Therefore, we have two objectives: (1) to experimentally characterize the angular distribution and proportion of minimally deviated quasiballistic photons and multiply scattered photons in a turbid medium and (2) to combine time and angular gating principles so that early and late arriving photons can be distinguished. From the angular distribution data, the angular filter with angular acceptance about 0.4 deg yields the highest image contrast for transillumination images. The use of angular domain imaging(ADI) with time-gating enables visualization of submillimeter absorbing objects with approximately seven times higher image contrast compared to ADI in a turbid medium with a scattering level of six times the reduced mean free path.

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© 2010 The International Society for Optical Engineering

Citation

Fartash Vasefi ; Mohamadreza Najiminaini ; Eldon Ng ; Bozena Kaminska ; Glenn H. Chapman, et al.
"Angular domain transillumination imaging optimization with an ultrafast gated camera", J. Biomed. Opt. 15(6), 061710 (November 17, 2010). ; http://dx.doi.org/10.1117/1.3505020


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