Research Papers: General

Study of laser-induced thermoelastic deformation of native and coagulated ex-vivo bovine liver tissues for estimating their optical and thermomechanical properties

[+] Author Affiliations
Behrouz Soroushian

Ryerson University, Department of Physics, Toronto, Canada M5B 2K3

William M. Whelan

University of Prince Edward Island, Department of Physics, Charlottetown, Canada C1A 4P3

Michael C. Kolios

Ryerson University, Department of Physics, Toronto, Canada M5B 2K3

J. Biomed. Opt. 15(6), 065002 (December 02, 2010). doi:10.1117/1.3517455
History: Received June 29, 2010; Revised October 05, 2010; Accepted October 07, 2010; Published December 02, 2010; Online December 02, 2010
Text Size: A A A

Several studies have explored the potential of optoacoustic imaging for monitoring thermal therapies, yet the origin of the contrast in the images is not well understood. A technique is required to measure the changes in the optical and thermomechanical properties of tissues upon coagulation to better understand this contrast. An interferometric method is presented for measuring simultaneously the optical and thermomechanical properties of native and coagulated ex-vivo bovine tissue samples based on analysis of the surface displacement of irradiated samples. Surface displacements are measured after irradiation by short laser pulses at 750 nm. A 51% decrease in the optical attenuation depth is observed for coagulated liver samples compared to native samples. No significant differences in the Grüneisen coefficient are measured in the native and coagulated tissue samples. A mean value of 0.12 for the Grüneisen coefficient is measured for both native and coagulated liver tissues. The displacement profiles exhibit consistent differences between the two tissue types. To assess the changes in the sample mechanical properties, the experimental data also are compared to numerical solutions of the equation for thermoelastic deformation. The results demonstrate that differences in the tissue expansion dynamics arise from higher values of elastic modulus for coagulated liver samples compared to native ones.

Figures in this Article
© 2010 Society of Photo-Optical Instrumentation Engineers

Citation

Behrouz Soroushian ; William M. Whelan and Michael C. Kolios
"Study of laser-induced thermoelastic deformation of native and coagulated ex-vivo bovine liver tissues for estimating their optical and thermomechanical properties", J. Biomed. Opt. 15(6), 065002 (December 02, 2010). ; http://dx.doi.org/10.1117/1.3517455


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement

 

 

  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.