Research Papers: Imaging

Imaging heterogeneous absorption distribution of advanced breast cancer by optical tomography

[+] Author Affiliations
Yan Xu, Quing Zhu

University of Connecticut Department of Electrical and Computer Engineering Storrs, Connecticut 06269

J. Biomed. Opt. 15(6), 066007 (December 08, 2010). doi:10.1117/1.3505015
History: Received May 17, 2010; Revised September 02, 2010; Accepted September 10, 2010; Published December 08, 2010; Online December 08, 2010
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Tumor vascular patterns of advanced breast cancers are complex and heterogeneous. Two typical light absorption patterns of periphery enhancement and posterior shadowing have been observed when imaging these advanced cancers using optical tomography guided by ultrasound. We perform a series simulation and phantom experiments to systemically evaluate the effects of target parameters, target locations, and target optical properties on imaging periphery enhancement absorption distribution using reflection geometry. Large tumors are modeled as concentric semiellipsoidal targets of different outer shell and inner core optical properties. We show that larger targets of more than 3 to 4 cm diameter with outer shell thicknesses less than 1 cm can be resolved at a depth less than 3 cm. A clinical example is given to show the complex vasculature distributions seen from an advanced cancer.

© 2010 Society of Photo-Optical Instrumentation Engineers

Citation

Yan Xu and Quing Zhu
"Imaging heterogeneous absorption distribution of advanced breast cancer by optical tomography", J. Biomed. Opt. 15(6), 066007 (December 08, 2010). ; http://dx.doi.org/10.1117/1.3505015


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