Research Papers: Imaging

Spectral hole burning for ultrasound-modulated optical tomography of thick tissue

[+] Author Affiliations
Xiao Xu, Sri-Rajasekhar Kothapalli, Honglin Liu, Lihong V. Wang

Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, St. Louis, Missouri 63130

J. Biomed. Opt. 15(6), 066018 (December 13, 2010). doi:10.1117/1.3505486
History: Received September 01, 2010; Revised September 28, 2010; Accepted September 29, 2010; Published December 13, 2010; December 16, 2010; Online December 13, 2010
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We apply spectral hole burning (SHB)-aided detection in ultrasound-modulated optical tomography (UOT) to image optical heterogeneities in thick tissue-mimicking phantom samples and chicken breast tissue. The efficiency of SHB is improved by using a Tm3+:YAG crystal of higher doping concentration (2.0-atomic%) and a double-pass pumping configuration, in which the pump beam is transmitted through the crystal twice to burn a deeper spectral hole with the available optical intensity. With the improved SHB-UOT system, we image absorbing, scattering, and phase objects that are embedded in the middle plane of a 30-mm-thick phantom sample. The imaging resolution was 0.5 mm in the lateral direction, as defined by the focal width of the ultrasonic transducer, and 1.5 mm in the axial direction, as determined by the ultrasonic burst length. We also image two absorbing objects embedded in a 32-mm-thick chicken breast sample. The results suggest that the improved SHB-UOT system is one step closer to the practical optical imaging application in biological and clinical studies.

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© 2010 Society of Photo-Optical Instrumentation Engineers

Citation

Xiao Xu ; Sri-Rajasekhar Kothapalli ; Honglin Liu and Lihong V. Wang
"Spectral hole burning for ultrasound-modulated optical tomography of thick tissue", J. Biomed. Opt. 15(6), 066018 (December 13, 2010). ; http://dx.doi.org/10.1117/1.3505486


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