Research Papers: Imaging

Current concepts and future perspectives on surgical optical imaging in cancer

[+] Author Affiliations
Vasilis Ntziachristos, Jung Sun Yoo

Technische Universität München, Helmholtz Zentrum München, Institute for Biological and Medical Imaging, Munich, Germany 80333

Gooitzen M. van Dam

University of Groningen, University Medical Center Groningen, Division of Abdominal and Surgical Oncology, Department of Surgery, BioOptical Imaging Center Groningen, Groningen, The Netherlands 9700 RB

J. Biomed. Opt. 15(6), 066024 (December 29, 2010). doi:10.1117/1.3523364
History: Received May 25, 2010; Revised September 24, 2010; Accepted October 11, 2010; Published December 29, 2010; Online December 29, 2010
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There are vibrant developments of optical imaging systems and contrast-enhancing methods that are geared to enhancing surgical vision and the outcome of surgical procedures. Such optical technologies designed for intraoperative use can offer high integration in the operating room compared to conventional radiological modalities adapted to intraoperative applications. Simple fluorescence epi-illumination imaging, in particular, appears attractive but may lead to inaccurate observations due to the complex nature of photon-tissue interaction. Of importance therefore are emerging methods that account for the background optical property variation in tissues and can offer accurate, quantitative imaging that eliminates the appearance of false negatives or positives. In parallel, other nonfluorescent optical imaging methods are summarized and overall progress in surgical optical imaging applications is outlined. Key future directions that have the potential to shift the paradigm of surgical health care are also discussed.

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© 2010 Society of Photo-Optical Instrumentation Engineers

Citation

Vasilis Ntziachristos ; Jung Sun Yoo and Gooitzen M. van Dam
"Current concepts and future perspectives on surgical optical imaging in cancer", J. Biomed. Opt. 15(6), 066024 (December 29, 2010). ; http://dx.doi.org/10.1117/1.3523364


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