Research Papers: General

Iris as a reflector for differential absorption low-coherence interferometry to measure glucose level in the anterior chamber

[+] Author Affiliations
Yong Zhou, Nan Zeng, Yao Li, Xiangsong Dai, Peng Li, Lian Duan, Hui Ma, Yonghong He

Tsinghua University, Laboratory of Optical Imaging and Sensing, Graduate School at Shenzhen, Shenzhen, 518055, China

Yanhong Ji

South China Normal University, MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, Guangzhou 510631, China

J. Biomed. Opt. 16(1), 015004 (January 20, 2011). doi:10.1117/1.3528658
History: Received May 31, 2010; Revised November 22, 2010; Accepted November 30, 2010; Published January 20, 2011; Online January 20, 2011
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We present a method of glucose concentration detection in the anterior chamber with a differential absorption optical low-coherent interferometry (LCI) technique. Back-reflected light from the iris, passing through the anterior chamber twice, was selectively obtained with the LCI technique. Two light sources, one centered within (1625 nm) and the other centered outside (1310 nm) of a glucose absorption band were used for differential absorption measurement. In the eye model and pig eye experiments, we obtained a resolution glucose level of 26.8 mg/dL and 69.6 mg/dL, respectively. This method has a potential application for noninvasive detection of glucose concentration in aqueous humor, which is related to the glucose concentration in blood.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Yong Zhou ; Nan Zeng ; Yanhong Ji ; Yao Li ; Xiangsong Dai, et al.
"Iris as a reflector for differential absorption low-coherence interferometry to measure glucose level in the anterior chamber", J. Biomed. Opt. 16(1), 015004 (January 20, 2011). ; http://dx.doi.org/10.1117/1.3528658


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