Research Papers: Imaging

Intraoperative imaging of cortical cerebral perfusion by time-resolved thermography and multivariate data analysis

[+] Author Affiliations
Gerald Steiner, Edmund Koch

Dresden University of Technology, Medical Faculty Carl Gustav Carus, Clinical Sensoring and Monitoring, 01307 Dresden, Germany

Stephan B. Sobottka, Gabriele Schackert, Matthias Kirsch

Dresden University of Technology, University Hospital, Department of Neurosurgery, 01307 Dresden, Germany

J. Biomed. Opt. 16(1), 016001 (January 26, 2011). doi:10.1117/1.3528011
History: Received June 08, 2010; Revised October 20, 2010; Accepted November 08, 2010; Published January 26, 2011; Online January 26, 2011
Text Size: A A A

A new approach to cortical perfusion imaging is demonstrated using high-sensitivity thermography in conjunction with multivariate statistical data analysis. Local temperature changes caused by a cold bolus are imaged and transferred to a false color image. A cold bolus of 10 ml saline at ice temperature is injected systemically via a central venous access. During the injection, a sequence of 735 thermographic images are recorded within 2 min. The recorded data cube is subjected to a principal component analysis (PCA) to select slight changes of the cortical temperature caused by the cold bolus. PCA reveals that 11 s after injection the temperature of blood vessels is shortly decreased followed by an increase to the temperature before the cold bolus is injected. We demonstrate the potential of intraoperative thermography in combination with multivariate data analysis to image cortical cerebral perfusion without any markers. We provide the first in vivo application of multivariate thermographic imaging.

Figures in this Article
© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Gerald Steiner ; Stephan B. Sobottka ; Edmund Koch ; Gabriele Schackert and Matthias Kirsch
"Intraoperative imaging of cortical cerebral perfusion by time-resolved thermography and multivariate data analysis", J. Biomed. Opt. 16(1), 016001 (January 26, 2011). ; http://dx.doi.org/10.1117/1.3528011


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.