Research Papers: Imaging

In vivo photoacoustic microscopy of human cutaneous microvasculature and a nevus

[+] Author Affiliations
Christopher P. Favazza, Lihong V. Wang

Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, One Brookings Drive, Campus Box 1097, St. Louis, Missouri 63130

Omar Jassim, Lynn A. Cornelius

Washington University School of Medicine, Division of Dermatology, 660 S. Euclid, Campus Box 8123, St. Louis, Missouri 63110

J. Biomed. Opt. 16(1), 016015 (January 28, 2011). doi:10.1117/1.3528661
History: Received July 08, 2010; Revised November 21, 2010; Accepted November 30, 2010; Published January 28, 2011; Online January 28, 2011
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In several human volunteers, photoacoustic microscopy (PAM) has been utilized for noninvasive cutaneous imaging of the skin microvasculature and a melanocytic nevus. Microvascular networks in both acral and nonacral skin were imaged, and multiple features within the skin have been identified, including the stratum corneum, epidermal-dermal junction, and subpapillary vascular plexus. Several vascular and structural differences between acral and nonacral skin were also observed in the photoacoustic images. In addition, a nevus was photoacoustically imaged, excised, and histologically analyzed. The photoacoustic images allowed for in vivo measurement of tumor thickness, depth, and microvasculature-values confirmed by histologic examination. The presented images demonstrate the potential of PAM to aid in the study and evaluation of cutaneous microcirculation and analysis of pigmented lesions. Through its ability to three-dimensionally image the structure and function of the microvasculature and pigmented lesions, PAM can have a clinical impact in diagnosis and assessment of systemic diseases that affect the microvasculature such as diabetes and cardiovascular disease, cutaneous malignancies such as melanoma, and potentially other skin disorders.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Christopher P. Favazza ; Omar Jassim ; Lynn A. Cornelius and Lihong V. Wang
"In vivo photoacoustic microscopy of human cutaneous microvasculature and a nevus", J. Biomed. Opt. 16(1), 016015 (January 28, 2011). ; http://dx.doi.org/10.1117/1.3528661


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