The field of nonlinear Raman microscopy is a field in motion. From the early days of the proof-of-principle coherent anti-Stokes Raman scattering (CARS) microscope in the early 1980s,1 to the 3-D CARS microscope with simplified collinear excitation geometry in 1999,2 the subsequent improvements in speed and contrast in the early years of the twenty-first century,3- 4 and the development of the background-free stimulated Raman scattering (SRS) imaging microscope,5 the field has always been driven by technological innovation. The push for better biomedical microscopes has brought together optical theorists, laser physicists, electrical engineers, microscope builders, fiber crafters, lens designers, and software programmers, who have jointly raised the performance of coherent Raman scattering (CRS) microscopes. Similar to Muybridge's advanced cameras, these technological improvements have continuously expanded the horizon of imaging applications. CRS microscopy enables the study of important aspects of tissue biology that have previously remained out of reach.