Research Papers: Imaging

Terahertz pulsed imaging study to assess remineralization of artificial caries lesions

[+] Author Affiliations
David Churchley, Richard J. M. Lynch

GlaxoSmithKline, St Georges Avenue, Weybridge, Surrey, KT13 0DE, United Kingdom

Frank Lippert, Jennifer Susan O’Bryan Eder

Indiana University School of Dentistry, Oral Heath Research Institute, 415 Lansing Street, Indianapolis, Indiana 46202

Jesse Alton

TeraView Ltd, Platinum Building, St John's Innovation Park, Cambridge CB4 0WS, United Kingdom

Carlos Gonzalez-Cabezas

University of Michigan, School of Dentistry, 1011 N. University B305, Ann Arbor, Michigan 48109–1078

J. Biomed. Opt. 16(2), 026001 (February 25, 2011). doi:10.1117/1.3540277
History: Received April 21, 2010; Revised November 15, 2010; Accepted December 03, 2010; Published February 25, 2011; Online February 25, 2011
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We compare terahertz–pulsed imaging (TPI) with transverse microradiography (TMR) and microindentation to measure remineralization of artificial caries lesions. Lesions are formed in bovine enamel using a solution of 0.1 M lactic acid/0.2% Carbopol C907 and 50% saturated with hydroxyapatite adjusted to pH 5.0. The 20-day experimental protocol consists of four 1 min treatment periods with dentifrices containing 10, 675, 1385, and 2700 ppm fluoride, a 4-h/day acid challenge, and, for the remaining time, specimens are stored in a 50:50 pooled human/artificial saliva mixture. Each specimen is imaged at the focal point of the terahertz beam (data-point spacing = 50 μm). The time-domain data are used to calculate the refractive index volume percent profile throughout the lesion, and the differences in the integrated areas between the baseline and post-treatment profiles are used to calculate ΔΔZ(THz). In addition, the change from baseline in both the lesion depth and the intensity of the reflected pulse from the air/enamel interface is determined. Statistically significant Pearson correlation coefficients are observed between TPI and TMR/microindentation (P < 0.05). We demonstrate that TPI has potential as a research tool for hard tissue imaging.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)


David Churchley ; Richard J. M. Lynch ; Frank Lippert ; Jennifer Susan O’Bryan Eder ; Jesse Alton, et al.
"Terahertz pulsed imaging study to assess remineralization of artificial caries lesions", J. Biomed. Opt. 16(2), 026001 (February 25, 2011). ; http://dx.doi.org/10.1117/1.3540277

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