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Research Papers: Imaging

Intravascular laser speckle imaging catheter for the mechanical evaluation of the arterial wall

[+] Author Affiliations
Zeinab Hajjarian, Jingqun Xi, Guillermo J. Tearney, Seemantini K. Nadkarni

Massachusetts General Hospital, Wellman Center for Photomedicine, Harvard Medical School, Boston, Massachusetts 02114

Farouc A. Jaffer

Massachusetts General Hospital, Cardiovascular Research Center and Cardiology Division, Boston, Massachusetts 02114

J. Biomed. Opt. 16(2), 026005 (February 10, 2011). doi:10.1117/1.3533322
History: Received September 09, 2010; Revised December 09, 2010; Accepted December 09, 2010; Published February 10, 2011; Online February 10, 2011
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Laser speckle imaging (LSI) is a novel technique for measuring the mechanical properties of atherosclerotic plaques. In LSI, the decorrelation time constant of speckle intensity fluctuations provides an index of viscoelasticity that is closely related to plaque microstructure and composition. Here, we demonstrate for the first time, the feasibility of conducting LSI in vivo using a prototype 1.5 mm (4.5 Fr) diameter intravascular catheter. Investigation of the catheter performance using human arterial samples ex vivo shows that plaque time constants measured by the LSI catheter correlate well with those measured using a free-space bulk optics system. To demonstrate LSI in vivo, the catheter is interfaced with a portable console for intravascular evaluation in the aorta of a living rabbit. Distinct differences in arterial time constants are identified at normal aortic and stented sites in vivo with intravascular LSI.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Zeinab Hajjarian ; Jingqun Xi ; Farouc A. Jaffer ; Guillermo J. Tearney and Seemantini K. Nadkarni
"Intravascular laser speckle imaging catheter for the mechanical evaluation of the arterial wall", J. Biomed. Opt. 16(2), 026005 (February 10, 2011). ; http://dx.doi.org/10.1117/1.3533322


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