0
Research Papers: Sensing

Intraoperative evaluation of revascularization effect on ischemic muscle hemodynamics using near-infrared diffuse optical spectroscopies

[+] Author Affiliations
Guoqiang Yu, Yu Shang, Ran Cheng, Lixin Dong

University of Kentucky, Center for Biomedical Engineering, Lexington, Kentucky 40506–0070

Youquan Zhao

University of Kentucky, Center for Biomedical Engineering, Lexington, Kentucky 40506–0070

Tianjin University, Department of Biomedical Engineering, Tianjin 300072, China

Sibu P. Saha

University of Kentucky, Cardiothoracic Surgery, Lexington, Kentucky 40536–0200

J. Biomed. Opt. 16(2), 027004 (February 15, 2011). doi:10.1117/1.3533320
History: Received August 25, 2010; Revised November 22, 2010; Accepted December 07, 2010; Published February 15, 2011; Online February 15, 2011
Text Size: A A A

Arterial revascularization in patients with peripheral arterial disease (PAD) reestablishes large arterial blood supply to the ischemic muscles in lower extremities via bypass grafts or percutaneous transluminal angioplasty (PTA). Currently no gold standard is available for assessment of revascularization effects in lower extremity muscles. This study tests a novel near-infrared diffuse correlation spectroscopy flow-oximeter for monitoring of blood flow and oxygenation changes in medial gastrocnemius (calf) muscles during arterial revascularization. Twelve limbs with PAD undergoing revascularization were measured using a sterilized fiber-optic probe taped on top of the calf muscle. The optical measurement demonstrated sensitivity to dynamic physiological events, such as arterial clamping/releasing during bypass graft and balloon inflation/deflation during PTA. Significant elevations in calf muscle blood flow were observed after revascularization in patients with bypass graft (+48.1 ± 17.5%) and patients with PTA (+43.2 ± 11.0%), whereas acute post-revascularization effects in muscle oxygenation were not evident. The decoupling of flow and oxygenation after revascularization emphasizes the need for simultaneous measurement of both parameters. The acute elevations/improvements in calf muscle blood flow were associated with significant improvements in symptoms and functions. In total, the investigation corroborates potential of the optical methods for objectively assessing the success of arterial revascularization.

Figures in this Article
© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Guoqiang Yu ; Yu Shang ; Youquan Zhao ; Ran Cheng ; Lixin Dong, et al.
"Intraoperative evaluation of revascularization effect on ischemic muscle hemodynamics using near-infrared diffuse optical spectroscopies", J. Biomed. Opt. 16(2), 027004 (February 15, 2011). ; http://dx.doi.org/10.1117/1.3533320


Access This Article
Sign In to Access Full Content
Please Wait... Processing your request... Please Wait.
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
 
Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement


Buy this article ($18 for members, $25 for non-members).
Sign In