Research Papers: General

Optimization of source and detector configurations based on Cramer–Rao lower bound analysis

[+] Author Affiliations
Ling Chen, Nanguang Chen

National University of Singapore, Division of Bioengineering, Faculty of Engineering, Singapore, 117576 Singapore

J. Biomed. Opt. 16(3), 035001 (March 09, 2011). doi:10.1117/1.3549738
History: Received July 13, 2010; Revised November 16, 2010; Accepted January 05, 2011; Published March 09, 2011; Online March 09, 2011
Text Size: A A A

Optimization of source and detector (SD) arrangements in a diffuse optical tomography system is helpful for improving measurements’ sensitivity to localized changes in imaging domain and enhancing the capacity of noise resistance. We introduced a rigorous and computationally efficient methodology and adapt it into the diffuse optics field to realize the optimizations of SD arrangements. Our method is based on Cramer–Rao lower bound analysis, which combines the diffusion-forward model and a noise model together. This method can be used to investigate the performance of the SD arrangements through quantitative estimations of lower bounds of the standard variances of the reconstructed perturbation depths and values. More importantly, it provides direct estimations of parameters without solving the inverse problem. Simulations are conducted in the reflection geometry to validate the effectiveness of the method on selections of the optimized SD sets, with a fixed number of sources and detectors, from an SD group on a planar probe surface. The impacts of different noise levels and target perturbation depths are considered in the simulations. It is demonstrated that the SD sets selected by this method afford better reconstructed images. This methodology can be adapted to other probe surfaces and other imaging geometries.

Figures in this Article
© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Topics

Sensors ; Simulations

Citation

Ling Chen and Nanguang Chen
"Optimization of source and detector configurations based on Cramer–Rao lower bound analysis", J. Biomed. Opt. 16(3), 035001 (March 09, 2011). ; http://dx.doi.org/10.1117/1.3549738


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.