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Research Papers: Imaging

Dark-field illuminated reflectance fiber bundle endoscopic microscope

[+] Author Affiliations
Xuan Liu, Yong Huang, Jin U. Kang

Johns Hopkins University, Department of Electrical and Computer Engineering, 3400 North Charles Street, Barton Hall, Baltimore, Maryland, 21218

J. Biomed. Opt. 16(4), 046003 (November 22, 2010February 04, 2011February 08, 2011April 05, 2011April 05, 2011). doi:10.1117/1.3560298
History: Received November 22, 2010; Revised February 04, 2011; Accepted February 08, 2011; Published April 05, 2011; Online April 05, 2011
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We propose a reflectance fiber bundle microscope using a dark-field illumination configuration for applications in endoscopic medical imaging and diagnostics. Our experiment results show that dark-field illumination can effectively suppress strong specular reflection from the proximal end of the fiber bundle. We realized a lateral resolution of 4.4 μm using the dark-field illuminated fiber bundle configuration. To demonstrate the feasibility of using the system to study cell morphology, we obtained still and video images of two thyroid cancer cell lines. Our results clearly allow differentiation of different cancer cell types.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Xuan Liu ; Yong Huang and Jin U. Kang
"Dark-field illuminated reflectance fiber bundle endoscopic microscope", J. Biomed. Opt. 16(4), 046003 (November 22, 2010February 04, 2011February 08, 2011April 05, 2011April 05, 2011). ; http://dx.doi.org/10.1117/1.3560298


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