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Research Papers: Imaging

Resting-state functional connectivity assessed with two diffuse optical tomographic systems

[+] Author Affiliations
Haijing Niu

Beijing Normal University, State Key Laboratory of Cognitive Neuroscience and Learning, Beijing 100875, China

University of Texas at Arlington, Department of Bioengineering, Joint Graduate Program between University of Texas at Arlington and University of Texas Southwestern Medical Center, Arlington, Texas 76019

Sabin Khadka, Fenghua Tian, Zi-Jing Lin, Hanli Liu

University of Texas at Arlington, Department of Bioengineering, Joint Graduate Program between University of Texas at Arlington and University of Texas Southwestern Medical Center, Arlington, Texas 76019

Chunming Lu, Chaozhe Zhu

Beijing Normal University, State Key Laboratory of Cognitive Neuroscience and Learning, Beijing 100875, China

J. Biomed. Opt. 16(4), 046006 (September 08, 2010February 10, 2011February 10, 2011April 01, 2011April 01, 2011). doi:10.1117/1.3561687
History: Received September 08, 2010; Revised February 10, 2011; Accepted February 10, 2011; Published April 01, 2011; Online April 01, 2011
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Functional near-infrared spectroscopy (fNIRS) is recently utilized as a new approach to assess resting-state functional connectivity (RSFC) in the human brain. For any new technique or new methodology, it is necessary to be able to replicate similar experiments using different instruments in order to establish its liability and reproducibility. We apply two different diffuse optical tomographic (DOT) systems (i.e., DYNOT and CW5), with various probe arrangements to evaluate RSFC in the sensorimotor cortex by utilizing a previously published experimental protocol and seed-based correlation analysis. Our results exhibit similar spatial patterns and strengths in RSFC between the bilateral motor cortexes. The consistent observations are obtained from both DYNOT and CW5 systems, and are also in good agreement with the previous fNIRS study. Overall, we demonstrate that the fNIRS-based RSFC is reproducible by various DOT imaging systems among different research groups, enhancing the confidence of neuroscience researchers and clinicians to utilize fNIRS for future applications.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Haijing Niu ; Sabin Khadka ; Fenghua Tian ; Zi-Jing Lin ; Chunming Lu, et al.
"Resting-state functional connectivity assessed with two diffuse optical tomographic systems", J. Biomed. Opt. 16(4), 046006 (September 08, 2010February 10, 2011February 10, 2011April 01, 2011April 01, 2011). ; http://dx.doi.org/10.1117/1.3561687


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