Research Papers: Imaging

Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system

[+] Author Affiliations
Patrick D. Kumavor, Chen Xu, Andres Aguirre, John Gamelin, Yasaman Ardeshirpour, Behnoosh Tavakoli, Saeid Zanganeh, Umar Alqasemi, Yi Yang, Quing Zhu

University of Connecticut, Electrical and Computer Engineering Department, 371 Fairfield Way, Unit 2157, Storrs, Connecticut 06269

J. Biomed. Opt. 16(4), 046010 (April 07, 2011). doi:10.1117/1.3563534
History: Received December 24, 2010; Revised February 13, 2011; Accepted February 16, 2011; Published April 07, 2011; April 20, 2011; Online April 07, 2011
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We present a photoacoustic tomography-guided diffuse optical tomography approach using a hand-held probe for detection and characterization of deeply-seated targets embedded in a turbid medium. Diffuse optical tomography guided by coregistered ultrasound, MRI, and x ray has demonstrated a great clinical potential to overcome lesion location uncertainty and to improve light quantification accuracy. However, due to the different contrast mechanisms, some lesions may not be detectable by a nonoptical modality but yet have high optical contrast. Photoacoustic tomography utilizes a short-pulsed laser beam to diffusively penetrate into tissue. Upon absorption of the light by the target, photoacoustic waves are generated and used to reconstruct, at ultrasound resolution, the optical absorption distribution that reveals optical contrast. However, the robustness of optical property quantification of targets by photoacoustic tomography is complicated because of the wide range of ultrasound transducer sensitivity, the orientation and shape of the targets relative to the ultrasound array, and the uniformity of the laser beam. We show in this paper that the relative optical absorption map provided by photoacoustic tomography can potentially guide the diffuse optical tomography to accurately reconstruct target absorption maps.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Patrick D. Kumavor ; Chen Xu ; Andres Aguirre ; John Gamelin ; Yasaman Ardeshirpour, et al.
"Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system", J. Biomed. Opt. 16(4), 046010 (April 07, 2011). ; http://dx.doi.org/10.1117/1.3563534


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