Research Papers: Imaging

Assessment of inflow and washout of indocyanine green in the adult human brain by monitoring of diffuse reflectance at large source-detector separation

[+] Author Affiliations
Adam Liebert, Piotr Sawosz, Daniel Milej, Michał Kacprzak, Marcin Botwicz, Roman Maniewski

Polish Academy of Sciences, Nalecz Institute of Biocybernetics and Biomedical Engineering, Trojdena 4, 02–109 Warsaw, Poland

Wojciech Weigl, Ewa Mayzner-Zawadzka

Medical University of Warsaw, Department of Anesthesiology and Intensive Care, Lindleya 4, Warsaw, 02–005 Poland

Joanna Mączewska, Katarzyna Fronczewska, Leszek Królicki

Medical University of Warsaw, Department of Nuclear Medicine, S. Banacha 1, Warsaw, 02–097 Poland

J. Biomed. Opt. 16(4), 046011 (April 26, 2011). doi:10.1117/1.3574018
History: Received August 09, 2010; Revised February 16, 2011; Accepted February 17, 2011; Published April 26, 2011; Online April 26, 2011
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Recently, it was shown in measurements carried out on humans that time-resolved near-infrared reflectometry and fluorescence spectroscopy may allow for discrimination of information originating directly from the brain avoiding influence of contaminating signals related to the perfusion of extracerebral tissues. We report on continuation of these studies, showing that the near-infrared light can be detected noninvasively on the surface of the tissue at large interoptode distance. A multichannel time-resolved optical monitoring system was constructed for measurements of diffuse reflectance in optically turbid medium at very large source-detector separation up to 9 cm. The instrument was applied during intravenous injection of indocyanine green and the distributions of times of flight of photons were successfully acquired showing inflow and washout of the dye in the tissue. Time courses of the statistical moments of distributions of times of flight of photons are presented and compared to the results obtained simultaneously at shorter source-detector separations (3, 4, and 5 cm). We show in a series of experiments carried out on physical phantom and healthy volunteers that the time-resolved data acquisition in combination with very large source-detector separation may allow one to improve depth selectivity of perfusion assessment in the brain.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Adam Liebert ; Piotr Sawosz ; Daniel Milej ; Michał Kacprzak ; Wojciech Weigl, et al.
"Assessment of inflow and washout of indocyanine green in the adult human brain by monitoring of diffuse reflectance at large source-detector separation", J. Biomed. Opt. 16(4), 046011 (April 26, 2011). ; http://dx.doi.org/10.1117/1.3574018


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