Research Papers: Sensing

Precision of cerebral oxygenation and hemoglobin concentration measurements in neonates measured by near-infrared spectroscopy

[+] Author Affiliations
Sandra Jasminder Arri, Martin Biallas, Hans Ulrich Bucher, Martin Wolf

University Hospital Zurich, Clinic of Neonatology, Department of Obstetrics and Gynecology, Frauenklinikstrasse 10, 8091 Zurich, Switzerland

Thomas Muehlemann

University Hospital Zurich, Clinic of Neonatology, Department of Obstetrics and Gynecology, Frauenklinikstrasse 10, 8091 Zurich, Switzerland

ETH and University of Zurich, Zurich, Switzerland

J. Biomed. Opt. 16(4), 047005 (April 21, 2011). doi:10.1117/1.3570303
History: Received March 22, 2010; Revised February 28, 2011; Accepted March 04, 2011; Published April 21, 2011; Online April 21, 2011
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Background and aim: One source of error with near-infrared spectroscopy (NIRS) is the assumption that the measured tissue is optically homogeneous. This is not always the case. Our aim is to assess the impact of tissue homogeneity (TH) on the precision of NIRS measurements in neonates. Methods: On 36 term and 27 preterm neonates at least five 1-min measurements are performed on each subject using the OxiplexTS. The sensor position is slightly changed before each measurement while assessing TH. The precision for cerebral tissue oxygenation saturation (StO2) and total hemoglobin concentration (tHb) are calculated by repeated measures analysis of variance. Results: The mean StO2 is not significantly different between term and preterm infants. The mean tHb is significantly lower in preterm infants (p < 0.01). With increasing TH, the precision of StO2 increase from 5.6 to 4.6% for preterm and from 11.0 to 2.0% for term infants; the precision of tHb increases from 10.1 to 7.5μM for preterm and from 16.4 to 3.5μM for term infants. The precision for StO2 is higher in term than in preterm infants. The precision for tHb shows no significant difference between the two groups. Conclusions: The precision of NIRS measurements correlates with tissue homogeneity.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Sandra Jasminder Arri ; Thomas Muehlemann ; Martin Biallas ; Hans Ulrich Bucher and Martin Wolf
"Precision of cerebral oxygenation and hemoglobin concentration measurements in neonates measured by near-infrared spectroscopy", J. Biomed. Opt. 16(4), 047005 (April 21, 2011). ; http://dx.doi.org/10.1117/1.3570303


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