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Special Section on Photonics and Nanotechnology in Biophysics and Biomedical Research

Survey on indirect optical manipulation of cells, nucleic acids, and motor proteins

[+] Author Affiliations
Ashis Gopal Banerjee

Massachusetts Institute of Technology, Computer Science and Artificial Intelligence Laboratory, Cambridge, Massachusetts 02139

Sagar Chowdhury, Satyandra K. Gupta

University of Maryland, Department of Mechanical Engineering, College Park, Maryland 20742

University of Maryland, The Institute for Systems Research, College Park, Maryland 20742

Wolfgang Losert

University of Maryland, Department of Physics, College Park, Maryland 20742

University of Maryland, Institute for Physical Science and Technology, College Park, Maryland 20742

University of Maryland, Institute for Research in Electronics and Applied Physics, College Park, Maryland 20742

J. Biomed. Opt. 16(5), 051302 (March 28, 2011March 25, 2011December 06, 2010May 12, 2011May 12, 2011). doi:10.1117/1.3579200
History: Accepted March 28, 2011; Revised March 25, 2011; Received December 06, 2010; Published May 12, 2011; Online May 12, 2011
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Optical tweezers have emerged as a promising technique for manipulating biological objects. Instead of direct laser exposure, more often than not, optically-trapped beads are attached to the ends or boundaries of the objects for translation, rotation, and stretching. This is referred to as indirect optical manipulation. In this paper, we utilize the concept of robotic gripping to explain the different experimental setups which are commonly used for indirect manipulation of cells, nucleic acids, and motor proteins. We also give an overview of the kind of biological insights provided by this technique. We conclude by highlighting the trends across the experimental studies, and discuss challenges and promising directions in this domain of active current research.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Ashis Gopal Banerjee ; Sagar Chowdhury ; Wolfgang Losert and Satyandra K. Gupta
"Survey on indirect optical manipulation of cells, nucleic acids, and motor proteins", J. Biomed. Opt. 16(5), 051302 (March 28, 2011March 25, 2011December 06, 2010May 12, 2011May 12, 2011). ; http://dx.doi.org/10.1117/1.3579200


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