0
Research Papers: Imaging

Real-time snapshot hyperspectral imaging endoscope

[+] Author Affiliations
Robert T. Kester, Noah Bedard

Rice University, Department of Bioengineering, 6100 Main Street, Houston, Texas 77005

Liang Gao

Rice University, Department of Bioengineering, 6100 Main Street, Houston, Texas 77005

Rice University, Rice Quantum Institute, 6100 Main Street, Houston, Texas 77005

Tomasz S. Tkaczyk

Rice University, Department of Bioengineering, 6100 Main Street, Houston, Texas 77005

Rice University, Department of Electrical and Computer Engineering, 6100 Main Street, Houston, Texas 77005

J. Biomed. Opt. 16(5), 056005 (May 10, 2011). doi:10.1117/1.3574756
History: Received August 05, 2010; Revised March 16, 2011; Accepted March 17, 2011; Published May 10, 2011; Online May 10, 2011
Text Size: A A A

Hyperspectral imaging has tremendous potential to detect important molecular biomarkers of early cancer based on their unique spectral signatures. Several drawbacks have limited its use for in vivo screening applications: most notably the poor temporal and spatial resolution, high expense, and low optical throughput of existing hyperspectral imagers. We present the development of a new real-time hyperspectral endoscope (called the image mapping spectroscopy endoscope) based on an image mapping technique capable of addressing these challenges. The parallel high throughput nature of this technique enables the device to operate at frame rates of 5.2 frames per second while collecting a (x, y, λ) datacube of 350 × 350 × 48. We have successfully imaged tissue in vivo, resolving a vasculature pattern of the lower lip while simultaneously detecting oxy-hemoglobin.

© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Robert T. Kester ; Noah Bedard ; Liang Gao and Tomasz S. Tkaczyk
"Real-time snapshot hyperspectral imaging endoscope", J. Biomed. Opt. 16(5), 056005 (May 10, 2011). ; http://dx.doi.org/10.1117/1.3574756


Access This Article
Sign In to Access Full Content
Please Wait... Processing your request... Please Wait.
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
 
Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement

Buy this article ($18 for members, $25 for non-members).
Sign In