Research Papers: Imaging

Extended scan depth optical coherence tomography for evaluating ocular surface shape

[+] Author Affiliations
Meixiao Shen, Jianhua Wang

University of Miami, Bascom Palmer Eye Institute, Department of Ophthalmology, 1638 NW 10th Avenue, Miami, Florida 33136

Lele Cui, Ming Li, Dexi Zhu

University of Miami, Bascom Palmer Eye Institute, Department of Ophthalmology, 1638 NW 10th Avenue, Miami, Florida 33136

Wenzhou Medical College, School of Optometry and Ophthalmology, 270 Xueyuan Road, Wenzhou 325027, China

Michael R. Wang

University of Miami, Electrical and Computer Engineering, 1251Memorial Drive, Coral Gables, Florida 33146

J. Biomed. Opt. 16(5), 056007 (May 10, 2011). doi:10.1117/1.3578461
History: Received October 13, 2010; Revised February 22, 2011; Accepted March 24, 2011; Published May 10, 2011; Online May 10, 2011
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Spectral domain optical coherence tomography (SD-OCT) with extended scan depth makes it possible for quantitative measurement of the entire ocular surface shape. We proposed a novel method for ocular surface shape measurement using a custom-built anterior segment SD-OCT, which will serve on the contact lens fitting. A crosshair alignment system was applied to reduce the misalignment and tilting of the eye. An algorithm was developed to automatically segment the ocular surface. We also described the correction of the image distortion from the segmented dataset induced by the nontelecentric scanning system and tested the accuracy and repeatability. The results showed high accuracy of SD-OCT in measuring a bicurved test surface with a maximum height error of 17.4 μm. The repeatability of in vivo measurement was also good. The standard deviations of the height measurement within a 14-mm wide range were all less than 35 μm. This work demonstrates the feasibility of using extended depth SD-OCT to perform noninvasive evaluation of the ocular surface shape.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Meixiao Shen ; Lele Cui ; Ming Li ; Dexi Zhu ; Michael R. Wang, et al.
"Extended scan depth optical coherence tomography for evaluating ocular surface shape", J. Biomed. Opt. 16(5), 056007 (May 10, 2011). ; http://dx.doi.org/10.1117/1.3578461


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