Research Papers: Imaging

Red-luminescent europium (III) doped silica nanoshells: synthesis, characterization, and their interaction with HeLa cells

[+] Author Affiliations
Jian Yang, Sharraya Aschemeyer, Andrew C. Kummel, William C. Trogler

University of California, San Diego, Department of Chemistry and Biochemistry, 9500 Gilman Drive, La Jolla, California 92093

Sergio Sandoval, Alex Liberman

University of California, San Diego, Department of Bioengineering, 9500 Gilman Drive, La Jolla, California 92093

Jesus G. Alfaro

University of California, San Diego, Department of Chemical Engineering, 9500 Gilman Drive, La Jolla, California 92093

David T. Martin

University of California, San Diego, Department of Computer and Electrical Engineering, 9500 Gilman Drive, La Jolla, California 92093

Milan Makale

University of California, San Diego, Moores Cancer Center, 9500 Gilman Drive, La Jolla, California 92093

J. Biomed. Opt. 16(6), 066012 (June 14, 2011). doi:10.1117/1.3593003
History: Received October 18, 2010; Revised April 20, 2010; Accepted April 26, 2011; Published June 14, 2011; Online June 14, 2011
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A simple method to fabricate Eu3+ doped silica nanoshells particles with 100 and 200 nm diameters is reported. Amino polystyrene beads were used as templates, and an 8 to 10 nm thick silica gel coating was formed by the sol-gel reaction. After removing the template by calcination, porous dehydrated silica gel nanoshells of uniform size were obtained. The Eu3+ doped silica nanoshells exhibited a red emission at 615 nm on UV excitation. The porous structure of the silica shell wall was characterized by transmission electron microscopy measurements, while particle size and zeta potentials of the particles suspended in aqueous solution were characterized by dynamic light scattering. Two-photon microscopy was used to image the nanoshells after assimilation by HeLa cancer cells.

Figures in this Article
© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Topics

Europium ; Silica

Citation

Jian Yang ; Sergio Sandoval ; Jesus G. Alfaro ; Sharraya Aschemeyer ; Alex Liberman, et al.
"Red-luminescent europium (III) doped silica nanoshells: synthesis, characterization, and their interaction with HeLa cells", J. Biomed. Opt. 16(6), 066012 (June 14, 2011). ; http://dx.doi.org/10.1117/1.3593003


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