Research Papers: Imaging

In vivo photoacoustic tomography of mouse cerebral edema induced by cold injury

[+] Author Affiliations
Zhun Xu, Lihong V. Wang

Washington University, Optical Imaging Laboratory, Department of Biomedical Engineering, St. Louis, Missouri 63130-4899

Quing Zhu

University of Connecticut, Department of Electrical and Computer Engineering, Storrs, Connecticut 06269

J. Biomed. Opt. 16(6), 066020 (June 01, 2011). doi:10.1117/1.3584847
History: Received February 16, 2011; Revised April 09, 2011; Accepted April 12, 2011; Published June 01, 2011; Online June 01, 2011
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For the first time, we have implemented photoacoustic tomography (PAT) to image the water content of an edema in vivo. We produced and imaged a cold-induced cerebral edema transcranially, then obtained blood vessel and water accumulation images at 610 and 975 nm, respectively. We tracked the changes at 12, 24, and 36 h after the cold injury. The blood volume decreased after the cold injury, and the maximum area of edema was observed 24 h after the cold injury. We validated PAT of the water content of the edema through magnetic Resonance Imaging and the water spectrum from the spectrophotometric measurement.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Zhun Xu ; Quing Zhu and Lihong V. Wang
"In vivo photoacoustic tomography of mouse cerebral edema induced by cold injury", J. Biomed. Opt. 16(6), 066020 (June 01, 2011). ; http://dx.doi.org/10.1117/1.3584847


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