Special Section on Hard-Tissue Optics and Related Methods

Quantitative evaluation of the kinetics of human enamel simulated caries using photothermal radiometry and modulated luminescence

[+] Author Affiliations
Adam Hellen

University of Toronto, Center for Advanced Diffusion-Wave Technologies, Department of Mechanical and Industrial Engineering, 5 King's College Road, Toronto, Ontario, M5S 3G8, Canada

University of Toronto, Faculty of Dentistry, 124 Edward Street, Toronto, Ontario, M5G 1G6, Canada

Andreas Mandelis

University of Toronto, Center for Advanced Diffusion-Wave Technologies, Department of Mechanical and Industrial Engineering, 5 King's College Road, Toronto, Ontario, M5S 3G8, Canada

University of Toronto, Institute of Biomaterials and Biomedical Engineering, 164 College Street, Toronto, Ontario, M5S 3G9, Canada

Quantum Dental Technologies, 748 Briar Hill Avenue, Toronto, Ontario, M6B 1L3, Canada

Yoav Finer

University of Toronto, Faculty of Dentistry, 124 Edward Street, Toronto, Ontario, M5G 1G6, Canada

Bennett T. Amaechi

University of Texas Health Science Center at San Antonio, Department of Comprehensive Dentistry, 7703 Floyd Curl Drive, San Antonio, Texas 78229-3900

J. Biomed. Opt. 16(7), 071406 (July 01, 2011). doi:10.1117/1.3564909
History: Received August 29, 2010; Revised November 09, 2010; Accepted December 07, 2010; Published July 01, 2011; Online July 01, 2011
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Photothermal radiometry and modulated luminescence (PTR-LUM) is an emerging nondestructive methodology applied toward the characterization and quantification of dental caries. We evaluate the efficacy of PTR-LUM in vitro to detect, monitor, and quantify human enamel caries. Artificial caries are created in extracted human molars (n = 15) using an acidified gel system (pH 4.5) for 10 or 40 days. PTR-LUM frequency scans (1 Hz–1 kHz) are performed before and during demineralization. Transverse microradiography (TMR) analysis, the current gold standard, follows at treatment conclusion to determine the mineral loss and depth of the artificially demineralized lesions. A theoretical model is applied to PTR experimental data to evaluate the changes in optothermophysical properties of demineralized enamel as a function of time. Higher optical scattering coefficients and poorer thermophysical properties are characteristic of the growing demineralized lesions, as verified by TMR, where the generated microporosities of the subsurface lesion confine the thermal-wave centroid. Enhanced optical scattering coefficients of demineralized lesions result in poorer luminescence yield due to scattering of both incident and converted luminescent photons. PTR-LUM sensitivity to changes in tooth mineralization coupled with opto-thermophysical property extraction illustrates the technique's potential for nondestructive quantification of enamel caries.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Adam Hellen ; Andreas Mandelis ; Yoav Finer and Bennett T. Amaechi
"Quantitative evaluation of the kinetics of human enamel simulated caries using photothermal radiometry and modulated luminescence", J. Biomed. Opt. 16(7), 071406 (July 01, 2011). ; http://dx.doi.org/10.1117/1.3564909


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