Research Papers: Imaging

Photoacoustic tomography of monkey brain using virtual point ultrasonic transducers

[+] Author Affiliations
Liming Nie, Zijian Guo, Lihong V. Wang

Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, One Brookings Drive, Campus Box 1097, St. Louis, Missouri 63130

J. Biomed. Opt. 16(7), 076005 (July 01, 2011). doi:10.1117/1.3595842
History: Received December 22, 2010; Revised April 08, 2011; Accepted May 09, 2011; Published July 01, 2011; Online July 01, 2011
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A photoacoustic tomography system (PAT) using virtual point ultrasonic transducers was developed and applied to image a monkey brain. The custom-built transducers provide a 10-fold greater field-of-view (FOV) than finite-aperture unfocused transducers as well as an improved signal-to-noise ratio (SNR) and reduced artifacts rather than negative-lens transducers. Their tangential resolution, radial resolution, and (SNR) improvements were quantified using tissue phantoms. Our PAT system can achieve high uniformity in both resolution (<1 mm) and SNR (>8) within a large FOV of 6 cm in diameter, even when the imaging objects are enclosed by a monkey skull. The cerebral cortex of a monkey brain was accurately mapped transcranially, through a skull ranging from 2 to 4 mm in thickness. This study demonstrates that PAT can overcome the optical and ultrasound attenuation of a relatively thick skull and can potentially be applied to human neonatal brain imaging.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Liming Nie ; Zijian Guo and Lihong V. Wang
"Photoacoustic tomography of monkey brain using virtual point ultrasonic transducers", J. Biomed. Opt. 16(7), 076005 (July 01, 2011). ; http://dx.doi.org/10.1117/1.3595842


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