Research Papers: Imaging

Multimodality approach to optical early detection and  mapping of oral neoplasia

[+] Author Affiliations
Yeh-Chan Ahn

Pukyong National University, Department of Biomedical Engineering, 45 Yongso-ro, Nam-gu, Busan, 608-737 Korea

Jungrae Chung, Petra Wilder-Smith

Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California 92612

Zhongping Chen

Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California 92612

University of California at Irvine, Department of Biomedical Engineering, Irvine, California 92612

Pusan National University, Department of Cogno-Mechatronics Engineering (WCU Program), Busan 609-735, Korea

J. Biomed. Opt. 16(7), 076007 (July 06, 2011). doi:10.1117/1.3595850
History: Received January 05, 2011; Revised April 28, 2011; Accepted May 10, 2011; Published July 06, 2011; Online July 06, 2011
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Early detection of cancer remains the best way to ensure patient survival and quality of life. Squamous cell carcinoma is usually preceded by dysplasia presenting as white, red, or mixed red and white epithelial lesions on the oral mucosa (leukoplakia, erythroplakia). Dysplastic lesions in the form of erythroplakia can carry a risk for malignant conversion of 90%. A noninvasive diagnostic modality would enable monitoring of these lesions at regular intervals and detection of treatment needs at a very early, relatively harmless stage. The specific aim of this work was to test a multimodality approach [three-dimensional optical coherence tomography (OCT) and polarimetry] to noninvasive diagnosis of oral premalignancy and malignancy using the hamster cheek pouch model (nine hamsters). The results were compared to tissue histopathology. During carcinogenesis, epithelial down grow, eventual loss of basement membrane integrity, and subepithelial invasion were clearly visible with OCT. Polarimetry techniques identified a four to five times increased retardance in sites with squamous cell carcinoma, and two to three times greater retardance in dysplastic sites than in normal tissues. These techniques were particularly useful for mapping areas of field cancerization with multiple lesions, as well as lesion margins.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Yeh-Chan Ahn ; Jungrae Chung ; Petra Wilder-Smith and Zhongping Chen
"Multimodality approach to optical early detection and  mapping of oral neoplasia", J. Biomed. Opt. 16(7), 076007 (July 06, 2011). ; http://dx.doi.org/10.1117/1.3595850


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