Research Papers: Imaging

In vivo determination of acute myocardial ischemia based on photoacoustic imaging with a focused transducer

[+] Author Affiliations
Zhifang Li

Fujian Normal University, Institute of Laser and Optoeletronics Technology, Key Laboratory of Optoelectronic Science and Technology for Medicine, Ministry of Education, Fujian Provincial Key Laboratory of Photonic Technology, Fuzhou, Fujian 350007, China

Fujian Medical University, Department of Cardiovascular Surgery, Fujian Provincial Hospital, Fuzhou, Fujian 350001, China

Hui Li, Wengming Xie

Fujian Normal University, Institute of Laser and Optoeletronics Technology, Key Laboratory of Optoelectronic Science and Technology for Medicine, Ministry of Education, Fujian Provincial Key Laboratory of Photonic Technology, Fuzhou, Fujian 350007, China

Haiyu Chen

Fujian Medical University, Department of Cardiovascular Surgery, Fujian Provincial Hospital, Fuzhou, Fujian 350001, China

J. Biomed. Opt. 16(7), 076011 (July 05, 2011). doi:10.1117/1.3598314
History: Received November 11, 2010; Revised May 05, 2011; Accepted May 18, 2011; Published July 05, 2011; Online July 05, 2011
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The location and ischemia extent are two important parameters for evaluating the acute myocardial ischemia (AMI). A focused-transducer-based photoacoustic imaging method was employed to assess time-dependent AMI. Our preliminary results show that the photoacoustic signal could identify the myocardium. The intensity and area of photoacoustic images of myocardium could be used for characterizing the ischemia extent and scope of myocardial ischemia. The results also imply that the intensity and area of photoacoustic images are the rapid fall of an exponential model with an increase of delaying time after the left anterior descending coronary artery (LAD) occlusion. These experimental results were consistent with the clinical characteristics. The findings suggest that the photoacoustic imaging be a potential tool for the real-time assessment of acute myocardial ischemia during surgical operation.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Zhifang Li ; Hui Li ; Haiyu Chen and Wengming Xie
"In vivo determination of acute myocardial ischemia based on photoacoustic imaging with a focused transducer", J. Biomed. Opt. 16(7), 076011 (July 05, 2011). ; http://dx.doi.org/10.1117/1.3598314


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