Research Papers: Sensing

Detection of localized inclusions of gold nanoparticles in Intralipid-1% by point-radiance spectroscopy

[+] Author Affiliations
Serge Grabtchak

University of Prince Edward Island, Department of Physics, Charlottetown, Prince Edward Island Canada C1A 4P3

Dalhousie University, Department of Electrical and Computer Engineering, Halifax, Nova Scotia Canada B3J 1Z1

Tyler J. Palmer

University of Prince Edward Island, Department of Physics, Charlottetown, Prince Edward Island Canada C1A 4P3

William M. Whelan

University of Prince Edward Island, Department of Physics, Charlottetown, Prince Edward Island Canada C1A 4P3

Atlantic Veterinary College, Department of Biomedical Sciences, Charlottetown, Prince Edward Island Canada C1A 4P3

J. Biomed. Opt. 16(7), 077003 (July 01, 2011). doi:10.1117/1.3597624
History: Received March 09, 2011; Revised April 28, 2011; Accepted May 16, 2011; Published July 01, 2011; Online July 01, 2011
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Interstitial fiber-optic–based approaches used in both diagnostic and therapeutic applications rely on localized light-tissue interactions. We present an optical technique to identify spectrally and spatially specific exogenous chromophores in highly scattering turbid media. Point radiance spectroscopy is based on directional light collection at a single point with a side-firing fiber that can be rotated up to 360 deg. A side firing fiber accepts light within a well-defined, solid angle, thus potentially providing an improved spatial resolution. Measurements were performed using an 800-μm diameter isotropic spherical diffuser coupled to a halogen light source and a 600 μm, ∼43 deg cleaved fiber (i.e., radiance detector). The background liquid-based scattering phantom was fabricated using 1% Intralipid. Light was collected with 1 deg increments through 360 deg-segment. Gold nanoparticles , placed into a 3.5-mm diameter capillary tube were used as localized scatterers and absorbers introduced into the liquid phantom both on- and off-axis between source and detector. The localized optical inhomogeneity was detectable as an angular-resolved variation in the radiance polar plots. This technique is being investigated as a potential noninvasive optical modality for prostate cancer monitoring.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Serge Grabtchak ; Tyler J. Palmer and William M. Whelan
"Detection of localized inclusions of gold nanoparticles in Intralipid-1% by point-radiance spectroscopy", J. Biomed. Opt. 16(7), 077003 (July 01, 2011). ; http://dx.doi.org/10.1117/1.3597624


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