Research Papers: Sensing

Studies on erythrocytes in malaria infected blood sample with Raman optical tweezers

[+] Author Affiliations
Raktim Dasgupta, Ravi Shanker Verma, Sunita Ahlawat, Abha Uppal, Pradeep Kumar Gupta

Raja Ramanna Centre for Advanced Technology, Laser Biomedical Applications and Instrumentation Division, Indore-452013, India

J. Biomed. Opt. 16(7), 077009 (July 01, 2011). doi:10.1117/1.3600011
History: Received December 24, 2009; Revised April 10, 2011; Accepted May 23, 2011; Published July 01, 2011; Online July 01, 2011
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Raman spectroscopy was performed on optically trapped red blood cells (RBCs) from blood samples of healthy volunteers (h-RBCs) and from patients suffering from P. vivax infection (m-RBCs). A significant fraction of m-RBCs produced Raman spectra with altered characteristics relative to h-RBCs. The observed spectral changes suggest a reduced oxygen-affinity or right shifting of the oxygen-dissociation curve for the intracellular hemoglobin in a significant fraction of m-RBCs with respect to its normal functional state.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Raktim Dasgupta ; Ravi Shanker Verma ; Sunita Ahlawat ; Abha Uppal and Pradeep Kumar Gupta
"Studies on erythrocytes in malaria infected blood sample with Raman optical tweezers", J. Biomed. Opt. 16(7), 077009 (July 01, 2011). ; http://dx.doi.org/10.1117/1.3600011


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