Research Papers: Therapeutic

Low-level laser therapy, at 60 J/cm2 associated with a Biosilicate® increase in bone deposition and indentation biomechanical properties of callus in osteopenic rats

[+] Author Affiliations
Renan Fangel, Paulo Sérgio Bossini, Patrícia Driusso, Nivaldo Antonio Parizotto

Federal University of São Carlos, Department of Physiotherapy, Rod. Washington Luiz, km 235, São Carlos, Sao Paulo 13600-970 Brazil

Ana Cláudia Renno, Daniel Araki Ribeiro

Federal University of Sao Paulo, Department of Bioscience, Av. Ana Costa, 95, Santos, Sao Paulo 11050240, Brazil

Charles Chenwei Wang, Keico Okino Nonaka

Federal University of São Carlos, Department of Biology, Rod. Washington Luiz, km 235, São Carlos, Sao Paulo 13600-970 Brazil

Renata Luri Toma

Federal University of Sao Paulo, Department of Physiotherapy, Av. Ana Costa, 95, Santos, Sao Paulo 11050240, Brazil

Jorge Oishi

Federal University of São Carlos, Department of Statistics, Rod. Washington Luiz, km 235, Sao Carlos, Sao Paulo 13565-2081, Brazil

J. Biomed. Opt. 16(7), 078001 (July 22, 2011). doi:10.1117/1.3598847
History: Received March 14, 2011; Revised May 19, 2011; Accepted May 19, 2011; Published July 22, 2011; Online July 22, 2011
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We investigate the effects of a novel bioactive material (Biosilicate®) and low-level laser therapy (LLLT), at 60 J/cm2, on bone-fracture consolidation in osteoporotic rats. Forty female Wistar rats are submitted to the ovariectomy, to induce osteopenia. Eight weeks after the ovariectomy, the animals are randomly divided into four groups, with 10 animals each: bone defect control group; bone defect filled with Biosilicate group; bone defect irradiated with laser at 60 J/cm2 group; bone defect filled with Biosilicate and irradiated with LLLT, at 60 J/cm2 group. Laser irradiation is initiated immediately after surgery and performed every 48 h for 14 days. Histopathological analysis points out that bone defects are predominantly filled with the biomaterial in specimens treated with Biosilicate. In the 60-J/cm2 laser plus Biosilicate group, the biomaterial fills all bone defects, which also contained woven bone and granulation tissue. Also, the biomechanical properties are increased in the animals treated with Biosilicate associated to lasertherapy. Our results indicate that laser therapy improves bone repair process in contact with Biosilicate as a result of increasing bone formation as well as indentation biomechanical properties.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Renan Fangel ; Paulo Sérgio Bossini ; Ana Cláudia Renno ; Daniel Araki Ribeiro ; Charles Chenwei Wang, et al.
"Low-level laser therapy, at 60 J/cm2 associated with a Biosilicate® increase in bone deposition and indentation biomechanical properties of callus in osteopenic rats", J. Biomed. Opt. 16(7), 078001 (July 22, 2011). ; http://dx.doi.org/10.1117/1.3598847


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