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Research Papers: Therapeutic

Studies of inactivation of encephalomyocarditis virus, M13 bacteriophage, and Salmonella typhimurium by using a visible femtosecond laser: insight into the possible inactivation mechanisms

[+] Author Affiliations
Kong T. Tsen, Stephanie Cope, Sara Vaiana

Arizona State University, Department of Physics, Tempe, Arizona 85287

Shaw-Wei D. Tsen

Washington University School of Medicine, St. Louis, Missouri 63110

Qiang Fu, Stuart M. Lindsay, Zhe Li

Arizona State University, Biodesign Institute, Tempe, Arizona 85287

Juliann G. Kiang

Uniformed Services University of the Health Sciences, Armed Forces Radiobiology Research Institute, Scientific Research Department, Bethesda, Maryland 20889-5603

Uniformed Services University of The Health Sciences, Armed Forces Radiobiology Research Institute, Department of Medicine, Bethesda, Maryland 20889-5603

Uniformed Services University of the Health Sciences, Armed Forces Radiobiology Research Institute, Department of Radiation Biology, Bethesda, Maryland 20889-5603

J. Biomed. Opt. 16(7), 078003 (July 12, 2011). doi:10.1117/1.3600771
History: Received March 10, 2011; Revised May 14, 2011; Accepted May 26, 2011; Published July 12, 2011; Online July 12, 2011
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We report experimental results on the inactivation of encephalomyocarditis virus, M13 bacteriophage, and Salmonella typhimurium by a visible femtosecond laser. Our results suggest that inactivation of virus and bacterium by a visible femtosecond laser involves completely different mechanisms. Inactivation of viruses by a visible femtosecond laser involves the breaking of hydrogen/hydrophobic bonds or the separation of the weak protein links in the protein shell of a viral particle. In contrast, inactivation of bacteria is related to the damage of their DNAs due to irradiation of a visible femtosecond laser. Possible mechanisms for the inactivation of viruses and bacteria are discussed.

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© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Kong T. Tsen ; Shaw-Wei D. Tsen ; Qiang Fu ; Stuart M. Lindsay ; Zhe Li, et al.
"Studies of inactivation of encephalomyocarditis virus, M13 bacteriophage, and Salmonella typhimurium by using a visible femtosecond laser: insight into the possible inactivation mechanisms", J. Biomed. Opt. 16(7), 078003 (July 12, 2011). ; http://dx.doi.org/10.1117/1.3600771


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