Research Papers: Imaging

Differential optical spectropolarimetric imaging system assisted by liquid crystal devices for skin imaging

[+] Author Affiliations
Ofir Aharon, Ibrahim Abdulhalim

Ben Gurion University of the Negev, Department of Electro-Optic Engineering, Beer Sheva 84105, Israel

Ofer Arnon, Eldad Silberstein

Soroka Hospital, Department of Plastic and Reconstructive Surgery and Burn Unit, Beer Sheva, 84105 Israel

Lior Rosenberg

Soroka Hospital, Department of Plastic and Reconstructive Surgery and Burn Unit, Beer Sheva, 84105 Israel

Ben Gurion University of the Negev, University Medical Center, Beer Sheva, 84105, Israel

Victor Dyomin

Soroka Hospital, Pathology Institute, Beer Sheva, 84105 Israel

J. Biomed. Opt. 16(8), 086008 (August 01, 2011). doi:10.1117/1.3609003
History: Received March 02, 2011; Revised June 09, 2011; Accepted June 17, 2011; Published August 01, 2011; Online August 01, 2011
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Skin cancer diagnosis depends not only on histopathological examination but also on visual inspection before and after the excision of suspected lesion. Neoplasm is accompanied with changes in birefringence of collagen, pleomorphicity, and hyperchromatic state of epithelial nuclei. These phenomena can be measured by spectral and polarization changes of light backscattered by the examined tissue. A new differential spectropolarimetric system is proposed using liquid crystal devices, one as a tunable filter and the other as a polarization rotator, both operating at wide spectral ranges from the visible to the near-infrared. Since collagen's fibrils texture orientation depends on its location in the skin and since it is not well organized, our system scans the bipolarization states by continuously rotating the linearly polarized light incident on a skin lesion, and collecting differential contrasts between sequenced images when simultaneously averaging the statistical readout of a video camera. This noninvasive method emphasizes areas on skin where the neoplasm, or tumor, minimizes the statistical polarization change of the scattered light from the lesion. The module can be considered as an assistant tool for epiluminescence microscopy. Images of skin tumors were captured in vivo before the patients having their surgery and compared to histopathological results.

© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Ofir Aharon ; Ibrahim Abdulhalim ; Ofer Arnon ; Lior Rosenberg ; Victor Dyomin, et al.
"Differential optical spectropolarimetric imaging system assisted by liquid crystal devices for skin imaging", J. Biomed. Opt. 16(8), 086008 (August 01, 2011). ; http://dx.doi.org/10.1117/1.3609003


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