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Research Papers: Imaging

First-in-human pilot study of a spatial frequency domain oxygenation imaging system

[+] Author Affiliations
Sylvain Gioux, Alan Stockdale, Rafiou Oketokoun, Nicholas J. Durr, Lorissa A. Moffitt

Beth Israel Deaconess Medical Center, Division of Hematology/Oncology, Department of Medicine, Boston, Massachusetts 02215

Amaan Mazhar, Bruce J. Tromberg

University of California, Department of Biomedical Engineering, Irvine, California 92612

Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92612

Bernard T. Lee, Samuel J. Lin, Adam M. Tobias

Beth Israel Deaconess Medical Center, Division of Plastic and Reconstructive Surgery, Boston, Massachusetts 02215

David J. Cuccia

Modulated Imaging Inc., Technology Incubator Office, 1002 Health Sciences Road, Irvine, California 92612

Yoshitomo Ashitate

Beth Israel Deaconess Medical Center, Division of Hematology/Oncology, Department of Medicine, Boston, Massachusetts 02215

Hokkaido University Graduate School of Medicine, Division of Cancer Diagnostics and Therapeutics, Sapporo, 060-8638 Japan

Edward Kelly

Brigham and Women's Hospital, Department of Surgery, Boston, Massachusetts 02115

Maxwell Weinmann

Brigham and Women's Hospital, Department of Anesthesia, Boston, Massachusetts 02115

Anthony J. Durkin

Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92612

John V. Frangioni

Beth Israel Deaconess Medical Center, Division of Hematology/Oncology, Department of Medicine, Boston, Massachusetts 02215

Beth Israel Deaconess Medical Center, Department of Radiology, Boston, Massachusetts 02215

J. Biomed. Opt. 16(8), 086015 (August 23, 2011). doi:10.1117/1.3614566
History: Received April 13, 2011; Revised June 30, 2011; Accepted July 01, 2011; Published August 23, 2011; Online August 23, 2011
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Oxygenation measurements are widely used in patient care. However, most clinically available instruments currently consist of contact probes that only provide global monitoring of the patient (e.g., pulse oximetry probes) or local monitoring of small areas (e.g., spectroscopy-based probes). Visualization of oxygenation over large areas of tissue, without a priori knowledge of the location of defects, has the potential to improve patient management in many surgical and critical care applications. In this study, we present a clinically compatible multispectral spatial frequency domain imaging (SFDI) system optimized for surgical oxygenation imaging. This system was used to image tissue oxygenation over a large area (16×12 cm) and was validated during preclinical studies by comparing results obtained with an FDA-approved clinical oxygenation probe. Skin flap, bowel, and liver vascular occlusion experiments were performed on Yorkshire pigs and demonstrated that over the course of the experiment, relative changes in oxygen saturation measured using SFDI had an accuracy within 10% of those made using the FDA-approved device. Finally, the new SFDI system was translated to the clinic in a first-in-human pilot study that imaged skin flap oxygenation during reconstructive breast surgery. Overall, this study lays the foundation for clinical translation of endogenous contrast imaging using SFDI.

Figures in this Article
© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation

Sylvain Gioux ; Amaan Mazhar ; Bernard T. Lee ; Samuel J. Lin ; Adam M. Tobias, et al.
"First-in-human pilot study of a spatial frequency domain oxygenation imaging system", J. Biomed. Opt. 16(8), 086015 (August 23, 2011). ; http://dx.doi.org/10.1117/1.3614566


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